Evaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acariçoba) in mice

The Hydrocotyle umbellata L. is a specimen of the Araliaceae family popularly known as acariçoba. Its indications in folk medicine include treatment of skin ulcers, and rheumatism. The aim of this study was to evaluate the antinociceptive and anti-inflammatory activities of the ethanolic extract fro...

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Published in:Anais da Academia Brasileira de Ciências 2013-09, Vol.85 (3), p.987-997
Main Authors: Florentino, Iziara F, Nascimento, Marcus Vinícius M, Galdino, Pablinny M, De Brito, Adriane F, Da Rocha, Fabio F, Tonussi, Carlos R, De Lima, Thereza Christina M, De Paula, José R, Costa, Elson A
Format: Article
Language:English
Subjects:
Acaricoba
Analgesics - isolation & purification
Analgesics - therapeutic use
Animals
anti-inflamatorio
Anti-Inflammatory Agents - isolation & purification
Anti-Inflammatory Agents - therapeutic use
antinociceptivo
Araliaceae - chemistry
Carrageenan
Ciencias Biomedicas
Edema - chemically induced
Edema - drug therapy
Hydrocotyle umbellata L
Male
Mice
MULTIDISCIPLINARY SCIENCES
Pain - chemically induced
Pain - drug therapy
Plant Extracts - therapeutic use
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Summary:The Hydrocotyle umbellata L. is a specimen of the Araliaceae family popularly known as acariçoba. Its indications in folk medicine include treatment of skin ulcers, and rheumatism. The aim of this study was to evaluate the antinociceptive and anti-inflammatory activities of the ethanolic extract from acariçoba's underground parts (EEA). EEA reduced the nociceptive response of the animals as evaluated in the acetic acid-induced writhing test and in both phases of formalin test. EEA also presented a supraspinal analgesic activity by increasing the pain latency in the hot plate test. Moreover, EEA reduced the leukocytes migration and plasma extravasation to pleural cavity in the carrageenan-induced pleurisy, besides reducing the edema induced by carrageenan until the second hour and also the edema induced by dextran. In conclusion our results showed that EEA of H. umbellata L. presents analgesic and anti-inflammatory activities, and that a blockade of activity or reduction in the release of different mediators, such as histamine and serotonin, could be involved in these pharmacologic effects.
ISSN:0001-3765
1678-2690
1678-2690
0001-3765
DOI:10.1590/S0001-37652013000300011