A Novel Acetone Sensor for Body Fluids

Ketones are well-known biomarkers of fat oxidation produced in the liver as a result of lipolysis. These biomarkers include acetoacetic acid and β-hydroxybutyric acid in the blood/urine and acetone in our breath and skin. Monitoring ketone production in the body is essential for people who use calor...

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Bibliographic Details
Published in:Biosensors (Basel) 2024-01, Vol.14 (1), p.4
Main Authors: Osorio Perez, Oscar, Nguyen, Ngan Anh, Hendricks, Asher, Victor, Shaun, Mora, Sabrina Jimena, Yu, Nanxi, Xian, Xiaojun, Wang, Shaopeng, Kulick, Doina, Forzani, Erica
Format: Article
Language:English
Subjects:
3-Hydroxybutyric Acid
Acetone
Acids
Analyzers
Biomarkers
Biosensors
Blood
Body Fluids
Body weight
Breath tests
Calibration
CMOS
Data analysis
Design and construction
Equipment and supplies
fat burning
fat oxidation
Health aspects
Humans
Humidity
Identification and classification
Ketones
Ketosis
Lipolysis
metabolic rate
Metabolism
Metal oxides
Monitoring methods
Oxidation
Physiological aspects
point of care
Semiconductors
Sensors
Spectrum analysis
Urine
wearable sensor
Weight control
Weight reduction
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Summary:Ketones are well-known biomarkers of fat oxidation produced in the liver as a result of lipolysis. These biomarkers include acetoacetic acid and β-hydroxybutyric acid in the blood/urine and acetone in our breath and skin. Monitoring ketone production in the body is essential for people who use caloric intake deficit to reduce body weight or use ketogenic diets for wellness or therapeutic treatments. Current methods to monitor ketones include urine dipsticks, capillary blood monitors, and breath analyzers. However, these existing methods have certain disadvantages that preclude them from being used more widely. In this work, we introduce a novel acetone sensor device that can detect acetone levels in breath and overcome the drawbacks of existing sensing approaches. The critical element of the device is a robust sensor with the capability to measure acetone using a complementary metal oxide semiconductor (CMOS) chip and convenient data analysis from a red, green, and blue deconvolution imaging approach. The acetone sensor device demonstrated sensitivity of detection in the micromolar-concentration range, selectivity for detection of acetone in breath, and a lifetime stability of at least one month. The sensor device utility was probed with real tests on breath samples using an established blood ketone reference method.
ISSN:2079-6374
2079-6374
DOI:10.3390/bios14010004