Brain functional changes in individuals with bulimia nervosa: a protocol for systematic review and meta-analysis

IntroductionBulimia nervosa (BN) is a disorder with high health and socioeconomic burdens that typically arises in late adolescence and early adulthood. Previous neuroimaging studies have found functional brain changes in patients with BN. This study aims to review the latest neurobiological evidenc...

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Published in:BMJ open 2022-04, Vol.12 (4), p.e052881-e052881
Main Authors: Sun, Yiming, Ye, Q, Wen, Q, Liu, X R, Sun, R, Dai, Y
Format: Article
Language:English
Subjects:
Adolescent
Adult
Bias
Brain - diagnostic imaging
Brain research
Bulimia
Bulimia Nervosa
Comorbidity
Eating disorders
Food
Humans
Hypotheses
Intervention
magnetic resonance imaging
Medical imaging
Meta-analysis
Meta-Analysis as Topic
neonatology
Neurology
neuroradiology
Neurosciences
Research Design
Software
Suicides & suicide attempts
Systematic review
Systematic Reviews as Topic
Teenagers
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creator Sun, Yiming
Ye, Q
Wen, Q
Liu, X R
Sun, R
Dai, Y
description IntroductionBulimia nervosa (BN) is a disorder with high health and socioeconomic burdens that typically arises in late adolescence and early adulthood. Previous neuroimaging studies have found functional brain changes in patients with BN. This study aims to review the latest neurobiological evidence from studies of individuals with BN, examine the consistency of these findings and evaluate the food addiction hypothesis of the disease.Methods and analysisA systematic search will be performed using the Cochrane Library, PubMed, Embase and Web of Science databases, covering the period from database inception to 30 November 2021. Two researchers will be responsible for study selection, quality assessment and data extraction. The anisotropic effect size version of the signed differential mapping method will be used to conduct a coordinate-based meta-analysis. Publication bias will be examined with the Egger test. The quality of studies will be evaluated using the Newcastle-Ottawa Scale.Ethics and disseminationNo ethics approval is required for this is a systematic review protocol and does not require the collection of primary data. Findings will be disseminated through peer-reviewed journal or related conferences.PROSPERO registration numberCRD42022307233.
doi_str_mv 10.1136/bmjopen-2021-052881
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Previous neuroimaging studies have found functional brain changes in patients with BN. This study aims to review the latest neurobiological evidence from studies of individuals with BN, examine the consistency of these findings and evaluate the food addiction hypothesis of the disease.Methods and analysisA systematic search will be performed using the Cochrane Library, PubMed, Embase and Web of Science databases, covering the period from database inception to 30 November 2021. Two researchers will be responsible for study selection, quality assessment and data extraction. The anisotropic effect size version of the signed differential mapping method will be used to conduct a coordinate-based meta-analysis. Publication bias will be examined with the Egger test. The quality of studies will be evaluated using the Newcastle-Ottawa Scale.Ethics and disseminationNo ethics approval is required for this is a systematic review protocol and does not require the collection of primary data. 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Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2022 Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. 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Previous neuroimaging studies have found functional brain changes in patients with BN. This study aims to review the latest neurobiological evidence from studies of individuals with BN, examine the consistency of these findings and evaluate the food addiction hypothesis of the disease.Methods and analysisA systematic search will be performed using the Cochrane Library, PubMed, Embase and Web of Science databases, covering the period from database inception to 30 November 2021. Two researchers will be responsible for study selection, quality assessment and data extraction. The anisotropic effect size version of the signed differential mapping method will be used to conduct a coordinate-based meta-analysis. Publication bias will be examined with the Egger test. The quality of studies will be evaluated using the Newcastle-Ottawa Scale.Ethics and disseminationNo ethics approval is required for this is a systematic review protocol and does not require the collection of primary data. 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Previous neuroimaging studies have found functional brain changes in patients with BN. This study aims to review the latest neurobiological evidence from studies of individuals with BN, examine the consistency of these findings and evaluate the food addiction hypothesis of the disease.Methods and analysisA systematic search will be performed using the Cochrane Library, PubMed, Embase and Web of Science databases, covering the period from database inception to 30 November 2021. Two researchers will be responsible for study selection, quality assessment and data extraction. The anisotropic effect size version of the signed differential mapping method will be used to conduct a coordinate-based meta-analysis. Publication bias will be examined with the Egger test. The quality of studies will be evaluated using the Newcastle-Ottawa Scale.Ethics and disseminationNo ethics approval is required for this is a systematic review protocol and does not require the collection of primary data. 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source BMJ Open Access Journals; BMJ Publishing; Publicly Available Content (ProQuest); PubMed Central
subjects Adolescent
Adult
Bias
Brain - diagnostic imaging
Brain research
Bulimia
Bulimia Nervosa
Comorbidity
Eating disorders
Food
Humans
Hypotheses
Intervention
magnetic resonance imaging
Medical imaging
Meta-analysis
Meta-Analysis as Topic
neonatology
Neurology
neuroradiology
Neurosciences
Research Design
Software
Suicides & suicide attempts
Systematic review
Systematic Reviews as Topic
Teenagers
title Brain functional changes in individuals with bulimia nervosa: a protocol for systematic review and meta-analysis
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