Retinal artery occlusion does not act as an independent marker of upcoming dementia: results from a Danish 20-year cohort study

PurposeRetinal artery occlusion (RAO) is a vision threatening disease associated with cerebral vascular dysfunction, which may reflect initial signs of cerebral pathology. Early detection of patients in risk of dementia could allow for preventative treatment. Hence, this study aimed to investigate R...

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Bibliographic Details
Published in:International journal of retina and vitreous 2023-08, Vol.9 (1), p.1-50, Article 50
Main Authors: Clausen, Anna Rebien, Stokholm, Lonny, Blaabjerg, Morten, Frederiksen, Katrine Hartmund, Pedersen, Frederik Nørregaard, Grauslund, Jakob
Format: Article
Language:English
Subjects:
Alzheimer's disease
Cardiovascular disease
Chronic obstructive pulmonary disease
Cohort analysis
Comorbidity
Dementia
Diabetes
Hypertension
Kidney diseases
Marital status
Ocular biomarkers
Original
Register-based study
Registration
Retinal artery occlusion
Sensitivity analysis
Vascular dementia
Veins & arteries
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Summary:PurposeRetinal artery occlusion (RAO) is a vision threatening disease associated with cerebral vascular dysfunction, which may reflect initial signs of cerebral pathology. Early detection of patients in risk of dementia could allow for preventative treatment. Hence, this study aimed to investigate RAO as an independent biomarker of incident dementia.MethodsThis study was a nationwide, 20-year longitudinal cohort study in Denmark with inclusion from 1998 to 2020 and follow up until the end of 2022. We identified 2 205 159 individuals aged 65 or older through the Danish national health registers and monitored RAO (exposure) and dementia (outcome) status. We calculated incidence rate and performed a Cox regression analysis with hazard ratio (HR) and 95% confidence interval (CI) for RAO as a marker of dementia in a crude, a semi-adjusted (age and sex), and a fully adjusted model (furthermore adjusted for marital status and systemic comorbidity.)ResultsWe identified 8 863 individuals with RAO. Incidence rates were higher among exposed compared to unexposed individuals (12.28 and 8.18 per 1000 person-years at risk, respectively). Individuals with RAO were more likely to be male and older at inclusion, to have hypertension, dyslipidaemia, cardiovascular disease, chronic kidney disease, and diabetes (p 
ISSN:2056-9920
2056-9920
DOI:10.1186/s40942-023-00488-3