Clerodane Furanoditerpenoids from Tinospora bakis (A.Rich.) Miers (Menispermaceae)

(A.Rich.) Miers (Menispermaceae) has traditionally been used to alleviate headaches, rheumatism, mycetoma, and diabetes, among others. Despite its extensive use, the active components of the plant have never been investigated. In this work, a series of furanoditerpenoids ( - ) and five compounds fro...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-12, Vol.29 (1), p.154
Main Authors: Kabbashi, Ahmed Saeed, Sattar, Maazah Abdul, Aamer, Muhammad, Siddiqui, Nimra Naz, Kamran, Muhammad, Fayaz, Aneela, Jahan, Humera, Khan, Farooq-Ahmad, Wang, Yan
Format: Article
Language:English
Subjects:
Antidiabetics
Communication
Diabetes
furanoditerpenoids
Glucose
Natural products
Phytochemicals
tinobakiside
tinobakisin
Tinospora bakis
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Summary:(A.Rich.) Miers (Menispermaceae) has traditionally been used to alleviate headaches, rheumatism, mycetoma, and diabetes, among others. Despite its extensive use, the active components of the plant have never been investigated. In this work, a series of furanoditerpenoids ( - ) and five compounds from other classes ( - ) were isolated from . Notably, two new compounds were discovered and named: tinobakisin ( ) and tinobakiside ( ). Their molecular structures were elucidated with NMR, MS, UV, IR, and ECD spectra. Additionally, known compounds ( - and - ) were corroboratively identified through spectral comparisons with previously reported data, while highlighting and addressing some inaccuracies in the prior literature. Remarkably, compounds , , , and exhibited a superior anti-glycation effect, outperforming established agents like rutin and quercetin in a lab model of protein glycation with glucose. The overall findings suggest that furanoditerpenoids play a crucial role in the antidiabetic properties of This research marks the first comprehensive phytochemical investigation of , opening the door for further investigation into furanoditerpenoids and their biological mechanisms.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29010154