Developmental Dysplasia of Hip: Perspectives in Genetic Screening

Development dysplasia of the hip (DDH) is a complex developmental disorder despite being a relatively common condition mainly caused by incompatibility of the femoral head and the abnormal joint socket. Development dysplasia of the hip describes a wide spectrum of disorders ranging from minor acetab...

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Bibliographic Details
Published in:Medical sciences (Basel) 2019-04, Vol.7 (4), p.59
Main Authors: Zamborsky, Radoslav, Kokavec, Milan, Harsanyi, Stefan, Attia, Doaa, Danisovic, Lubos
Format: Article
Language:English
Subjects:
associated genes
Chromosomes
Cytochrome
DDH screening
developmental dysplasia of hip
Disease
Genes
genetic factors
Genomes
Health risk assessment
Methods
Pathology
Review
Ultrasonic imaging
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Summary:Development dysplasia of the hip (DDH) is a complex developmental disorder despite being a relatively common condition mainly caused by incompatibility of the femoral head and the abnormal joint socket. Development dysplasia of the hip describes a wide spectrum of disorders ranging from minor acetabular dysplasia to irreducible dislocation of the hip. Modern medicine still suffers from lack of information about screening and precise genetic examination. Genome wide linkage and association studies have brought significant progress to DDH diagnosis. Association studies managed to identify many candidate (susceptible) genes, such as , , , , and , which play a considerable role in the pathogenesis of DDH. Early detection of DDH has a big chance to help in preventing further disability and improve the psychological health and quality of life in those children. This emphasizes the importance to establish a universal screening program along with the genetic counseling.
ISSN:2076-3271
2076-3271
DOI:10.3390/medsci7040059