Clinical Relevance of HLA Antibody Monitoring after Kidney Transplantation

In kidney transplantation, antibody-mediated allograft injury caused by donor HLA-specific antibodies (DSA) has recently been identified as one of the major causes of late graft loss. This paper gives a brief overview on the impact of DSA development on graft outcome in organ transplantation with a...

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Bibliographic Details
Published in:Journal of immunology research 2014-01, Vol.2014 (2014), p.1-5
Main Authors: Süsal, Caner, Zeier, Martin, Opelz, Gerhard, Morath, Christian
Format: Article
Language:English
Subjects:
Graft Rejection - diagnosis
Graft Rejection - etiology
Graft Rejection - immunology
Histocompatibility Testing
HLA Antigens - immunology
Humans
Immunology
Isoantibodies - immunology
Kidney Transplantation - adverse effects
Kidney Transplantation - methods
Monitoring, Physiologic - methods
Review
Risk Factors
Transplantation, Homologous
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Summary:In kidney transplantation, antibody-mediated allograft injury caused by donor HLA-specific antibodies (DSA) has recently been identified as one of the major causes of late graft loss. This paper gives a brief overview on the impact of DSA development on graft outcome in organ transplantation with a focus on risk factors for de novo alloantibody induction and recently published guidelines for monitoring of DSA during the posttransplant phase.
ISSN:2314-8861
2314-7156
DOI:10.1155/2014/845040