Curcumin Incorporation into Zn3Al Layered Double Hydroxides—Preparation, Characterization and Curcumin Release

Curcumin (CR) is a natural antioxidant compound extracted from Curcuma longa (turmeric). Until now, researches related to the incorporation of CR into layered double hydroxides (LDHs) were focused only on hybrid structures based on a MgxAl-LDH matrix. Our studies were extended towards the incorporat...

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Bibliographic Details
Published in:Crystals (Basel) 2020-04, Vol.10 (4), p.244
Main Authors: Pavel, Octavian D., Şerban, Ariana, Zăvoianu, Rodica, Bacalum, Elena, Bîrjega, Ruxandra
Format: Article
Language:English
Subjects:
Antioxidants
Aqueous solutions
Bioavailability
Buffer solutions
Caustic soda
curcumin
Direct reduction
drug release
Enzymes
Hybrid structures
Hydrochloric acid
Hydroxides
layered double hydroxides
Nanoparticles
Nitrates
Potassium
reconstruction
Reflectance
Zinc oxide
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Summary:Curcumin (CR) is a natural antioxidant compound extracted from Curcuma longa (turmeric). Until now, researches related to the incorporation of CR into layered double hydroxides (LDHs) were focused only on hybrid structures based on a MgxAl-LDH matrix. Our studies were extended towards the incorporation of CR in another type of LDH-matrix (Zn3Al-LDH) which could have an even more prolific effect on the antioxidant activity due to the presence of Zn. Four CR-modified Zn3Al-LDH solids were synthesized, e.g., PZn3Al-CR(Aq), PZn3Al-CR(Et), RZn3Al-CR(Aq) and RZn3Al-CR(Et) (molar ratio CR/Al = 1/10, where P and R stand for the preparation method (P = precipitation, R = reconstruction), while (Aq) and (Et) indicate the type of CR solution, aqueous or ethanolic, respectively). The samples were characterized by XRD, Attenuated Total Reflectance Fourier Transformed IR (ATR-FTIR) and diffuse reflectance (DR)-UV–Vis techniques and the CR-release was investigated in buffer solutions at different pH values (1, 2, 5, 7 and 8). XRD results indicated a layered structure for PZn3Al-CR(Aq), PZn3Al-CR(Et), RZn3Al-CR(Aq) impurified with ZnO, while RZn3Al-CR(Et) contained ZnO nano-particles as the main crystalline phase. For all samples, CR-release revealed a decreasing tendency towards the pH increase, and higher values were obtained for RZn3Al-CR(Et) and PZn3Al-CR(Et) (e.g., 45% and 25%, respectively at pH 1).
ISSN:2073-4352
2073-4352
DOI:10.3390/cryst10040244