Apoptotic neuron-secreted HN12 inhibits cell apoptosis in Hirschsprung's disease

Perturbation in apoptosis can lead to Hirschsprung's disease (HSCR), which is a genetic disorder of neural crest development. It is believed that long noncoding RNAs (lncRNAs) play a role in the progression of HSCR. This study shows that apoptotic neurons can suppress apoptosis of nonapoptotic...

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Bibliographic Details
Published in:International journal of nanomedicine 2016, Vol.11, p.5871-5881
Main Authors: Du, Chunxia, Xie, Hua, Zang, Rujin, Shen, Ziyang, Li, Hongxing, Chen, Pingfa, Xu, Xiaoqun, Xia, Yankai, Tang, Weibing
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Alzheimer's disease
Apoptosis
Apoptosis - genetics
Biomarkers - metabolism
Cancer
Case-Control Studies
Cell adhesion & migration
Cell Line
Colon - pathology
Congenital diseases
Cytochrome c
Cytochromes c - metabolism
Exosomal long non-coding RNA
Exosomes - metabolism
Experiments
Female
Gene Expression Regulation
Hirschsprung disease
Hirschsprung Disease - diagnosis
Hirschsprung Disease - genetics
Hirschsprung Disease - pathology
Humans
Infant, Newborn
Intercellular communication
Laboratories
Male
MicroRNAs
Microscopy
Mitochondria
Mitochondria - genetics
Mitochondria - pathology
Nervous system
Neuronal development
Neurons
Neurons - metabolism
Neurons - pathology
Original Research
Pediatrics
Peptides
Proteins - chemistry
Proteins - genetics
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Stem cells
Surgery
Toxicology
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Summary:Perturbation in apoptosis can lead to Hirschsprung's disease (HSCR), which is a genetic disorder of neural crest development. It is believed that long noncoding RNAs (lncRNAs) play a role in the progression of HSCR. This study shows that apoptotic neurons can suppress apoptosis of nonapoptotic cells by secreting exosomes that contain high levels of HN12 lncRNA. Elevated exogenous HN12 in nonapoptotic cells effectively inhibited cell apoptosis by maintaining the function of mitochondria, including the production of ATP and the release of cytochrome C. These results demonstrate that secreted lncRNAs may serve as signaling molecules mediating intercellular communication in HSCR. In addition, high HN12 levels in the circulation worked as a biomarker for predicting HSCR, providing a potential, novel, noninvasive diagnostic approach for early screening of HSCR.
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S114838