Ultrasound-enhanced biosynthesis of uniform ZnO nanorice using Swietenia macrophylla seed extract and its in vitro anticancer activity

In this study, ultrasonically driven biosynthesis of zinc oxide nanoparticles (ZnO NPs) using seed ethyl acetate fraction (SMEAF) has been reported. X-ray powder diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) analyses confirmed the presence of a pure hexagonal wurtzite structur...

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Bibliographic Details
Published in:Nanotechnology reviews (Berlin) 2021-01, Vol.10 (1), p.572-585
Main Authors: Low, Darren Yi Sern, Mahendra, Camille Keisha, Supramaniam, Janarthanan, Tan, Loh Teng Hern, Lee, Learn Han, Manickam, Sivakumar, Goh, Bey Hing, Tan, Khang Wei, Tang, Siah Ying
Format: Article
Language:English
Subjects:
Acetic acid
anticancer
Anticancer properties
Antitumor activity
Antitumor agents
Biomedical materials
Biosynthesis
Cell viability
Colon
Colon cancer
Colorectal cancer
Ethyl acetate
Field emission microscopy
Fourier transforms
Herbal medicine
Infrared analysis
Infrared spectroscopy
Medicinal plants
Nanoparticles
NPs
Plant extracts
Scanning electron microscopy
Swietenia macrophylla
Tumor cell lines
Ultrasonic imaging
Ultrasound
Wurtzite
X ray powder diffraction
X-ray diffraction
Zinc oxide
Zinc oxides
ZnO
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Summary:In this study, ultrasonically driven biosynthesis of zinc oxide nanoparticles (ZnO NPs) using seed ethyl acetate fraction (SMEAF) has been reported. X-ray powder diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) analyses confirmed the presence of a pure hexagonal wurtzite structure of ZnO. Field emission scanning electron microscope images revealed the formation of uniquely identifiable uniform rice-shaped biologically synthesized ZnO particles. The particle sizes of the biosynthesized NPs ranged from 262 to 311 nm. The underlying mechanisms for the biosynthesis of ZnO under ultrasound have been proposed based on FTIR and XRD results. The anticancer activity of the as-prepared ZnO was investigated against HCT-116 human colon cancer cell lines methyl thiazolyl tetrazolium assay. ZnO exhibited significant anticancer activity against colon cancer cells with higher potency than ZnO particles prepared using the chemical method and SMEAF alone. Exposure of HCT-116 colon cancer cells to ZnO promoted a remarkable reduction in cell viability in all the tested concentrations. This study suggests that green sonochemically induced ZnO NPs using medicinal plant extract could be a potential anticancer agent for biomedical applications.
ISSN:2191-9097
2191-9089
2191-9097
DOI:10.1515/ntrev-2021-0044