Vitamin A, E, and D Deficiencies in Tunisian Very Low Birth Weight Neonates: Prevalence and Risk Factors

Background Preterm neonates are at high risk of vitamin deficiencies, which may expose them to increased morbidity and mortality. This study aimed to determine the prevalence and risk factors for vitamin A, E, and D deficiencies in Tunisian very low birth weight (VLBW) neonates. Methods A total of 6...

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Bibliographic Details
Published in:Pediatrics and neonatology 2014-06, Vol.55 (3), p.196-201
Main Authors: Fares, Samira, Sethom, Mohamed Marouane, Khouaja-Mokrani, Chahnez, Jabnoun, Sami, Feki, Moncef, Kaabachi, Naziha
Format: Article
Language:English
Subjects:
Internal Medicine
Pediatrics
pre-eclampsia
preterm neonate
very low birth weight
vitamin deficiency
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Summary:Background Preterm neonates are at high risk of vitamin deficiencies, which may expose them to increased morbidity and mortality. This study aimed to determine the prevalence and risk factors for vitamin A, E, and D deficiencies in Tunisian very low birth weight (VLBW) neonates. Methods A total of 607 VLBW and 300 term neonates were included in the study. Plasma vitamins A and E were assessed by high performance liquid chromatography and vitamin D was assessed by radioimmunoassay. Results Prevalence of vitamin A, E, and D deficiencies were dramatically elevated in VLBW neonates and were significantly higher than term neonates (75.9% vs. 63.3%; 71.3% vs. 55.5%; and 65.2% vs. 40.4%, respectively). In VLBW neonates, the prevalence of vitamin deficiencies was significantly higher in lower classes of gestational age and birth weight. Vitamin E deficiency was associated with pre-eclampsia [odds ratio (OR) (95% confidence interval, 95% CI), 1.56 (1.01–2.44); p  
ISSN:1875-9572
DOI:10.1016/j.pedneo.2013.09.006