Design of a water-soluble chitosan-based polymer with antioxidant and chelating properties for labile iron extraction

Loosely bound iron, due to its contribution to oxidative stress and inflammation, has become an important therapeutic target for many diseases. A water-soluble chitosan-based polymer exhibiting both antioxidant and chelating properties due to the dual functionalization with DOTAGA and DFO has been d...

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Bibliographic Details
Published in:Scientific reports 2023-05, Vol.13 (1), p.7920-7920, Article 7920
Main Authors: Grange, Coralie, Aigle, Axel, Ehrlich, Victor, Salazar Ariza, Juan Felipe, Brichart, Thomas, Da Cruz-Boisson, Fernande, David, Laurent, Lux, François, Tillement, Olivier
Format: Article
Language:English
Subjects:
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Alzheimer's disease
Antioxidants
Chelation therapy
Chitosan
Dialysate
Hemodialysis
Homeostasis
Humanities and Social Sciences
Intensive care
Iron
Liver diseases
Metabolism
Mortality
multidisciplinary
Oxidation
Oxidative stress
Physics
Plasma
Polymers
Proteins
Reactive oxygen species
Science
Science (multidisciplinary)
Therapeutic targets
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Summary:Loosely bound iron, due to its contribution to oxidative stress and inflammation, has become an important therapeutic target for many diseases. A water-soluble chitosan-based polymer exhibiting both antioxidant and chelating properties due to the dual functionalization with DOTAGA and DFO has been developed to extract this iron therefore preventing its catalytic production of reactive oxygen species. This functionalized chitosan was shown to have stronger antioxidant properties compared to conventional chitosan, improved iron chelating properties compared to the clinical therapy, deferiprone, and provided promising results for its application and improved metal extraction within a conventional 4 h hemodialysis session with bovine plasma.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-34251-3