LncRNA-mediated DNA methylation: an emerging mechanism in cancer and beyond

DNA methylation is one of the most important epigenetic mechanisms to regulate gene expression, which is highly dynamic during development and specifically maintained in somatic cells. Aberrant DNA methylation patterns are strongly associated with human diseases including cancer. How are the cell-sp...

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Bibliographic Details
Published in:Journal of experimental & clinical cancer research 2022-03, Vol.41 (1), p.100-100, Article 100
Main Authors: Huang, Wanxu, Li, Hua, Yu, Qingsong, Xiao, Wei, Wang, Dan Ohtan
Format: Article
Language:English
Subjects:
Cancer
Developmental biology
DNA
DNA methylation
DNA Methylation - genetics
DNMT
Epigenetic inheritance
Gene expression
Genes
Genetic aspects
Humans
lncRNA
Mediation
Methylation
Methyltransferases
Neoplasms - genetics
Non-coding RNA
Physiological aspects
Review
RNA
RNA, Long Noncoding - metabolism
TET
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Summary:DNA methylation is one of the most important epigenetic mechanisms to regulate gene expression, which is highly dynamic during development and specifically maintained in somatic cells. Aberrant DNA methylation patterns are strongly associated with human diseases including cancer. How are the cell-specific DNA methylation patterns established or disturbed is a pivotal question in developmental biology and cancer epigenetics. Currently, compelling evidence has emerged that long non-coding RNA (lncRNA) mediates DNA methylation in both physiological and pathological conditions. In this review, we provide an overview of the current understanding of lncRNA-mediated DNA methylation, with emphasis on the roles of this mechanism in cancer, which to the best of our knowledge, has not been systematically summarized. In addition, we also discuss the potential clinical applications of this mechanism in RNA-targeting drug development.
ISSN:1756-9966
0392-9078
1756-9966
DOI:10.1186/s13046-022-02319-z