Association of tissue oxygen saturation levels with skeletal muscle injury in the critically ill

This study aimed to investigate the association between the level of tissue oxygen saturation (StO 2 ) and quadriceps/skeletal muscle dysfunction, measured using the Medical Research Council (MRC) scale and ultrasonography, in critically ill patients. Thirty-four patients hospitalized at the Critica...

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Bibliographic Details
Published in:Scientific reports 2024-02, Vol.14 (1), p.4811-4811, Article 4811
Main Authors: Sugiya, Ryuji, Arizono, Shinichi, Higashimoto, Yuji, Kimoto, Yuta, Shiraishi, Masashi, Mizusawa, Hiroki, Tawara, Yuichi, Shigeoka, Hironori, Bakker, Jan, Shinozaki, Koichiro
Format: Article
Language:English
Subjects:
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Atrophy
Cross-sectional area
Humanities and Social Sciences
Infrared spectroscopy
Medical research
Medical Research Council (MRC) scale
multidisciplinary
Musculoskeletal system
Near-infrared spectroscopy
Oxygen saturation
Patients
Quadriceps muscle
Rectus femoris
Science
Science (multidisciplinary)
Skeletal muscle
Tissue oxygen saturation
Ultrasonography
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Summary:This study aimed to investigate the association between the level of tissue oxygen saturation (StO 2 ) and quadriceps/skeletal muscle dysfunction, measured using the Medical Research Council (MRC) scale and ultrasonography, in critically ill patients. Thirty-four patients hospitalized at the Critical Care Medicine Center of Kindai University Hospital, between January 2022 and March 2023, were enrolled in this study. The StO 2 of the quadriceps muscle was measured via near-infrared spectroscopy. Muscle atrophy was measured by the thickness, cross-sectional area (CSA), and echo intensity of the rectus femoris (RF). These values were evaluated every alternate day until 13 days after admission or until discharge, whichever occurred first. Muscle weakness was assessed using the sum score of the MRC scale (MRC-SS), with the patient sitting at bedside. The mean age of the patients was 67.3 ± 15.3 years, and 20 (59%) were men. Seven patients (21%) were admitted for trauma, and 27 (79%) were admitted for medical emergencies or others. The mean score for the MRC-SS was 51.0 ± 7.9 points. RF thickness and CSA significantly decreased after day 7 ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-55118-1