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Adsorption of bisphenol A to a carbon nanotube reduced its endocrine disrupting effect in mice male offspring

Soluble carbon nanotubes (CNTs) have shown promise as materials for adsorption of environmental contaminants such as Bisphenol A (BPA), due to the high adsorption capacity and strong desorption hysteresis of BPA on CNTs. The adsorption of BPA to CNTs may change the properties of both BPA and CNTs, a...

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Published in:International journal of molecular sciences 2014-09, Vol.15 (9), p.15981-15993
Main Authors: Wang, Wenwei, Jiang, Cuijuan, Zhu, Ledong, Liang, Nana, Liu, Xuejiao, Jia, Jianbo, Zhang, Chengke, Zhai, Shumei, Zhang, Bin
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cited_by cdi_FETCH-LOGICAL-c547t-a3ef0ad5d8afc0dfb6979eef9ed39b18e7ae9f37936583d4a0cb9eed43adbd663
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container_title International journal of molecular sciences
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Zhang, Bin
description Soluble carbon nanotubes (CNTs) have shown promise as materials for adsorption of environmental contaminants such as Bisphenol A (BPA), due to the high adsorption capacity and strong desorption hysteresis of BPA on CNTs. The adsorption of BPA to CNTs may change the properties of both BPA and CNTs, and induce different toxicity to human and living systems from that of BPA and CNTs alone. Herein, we report that oral exposure of BPA/MWCNT-COOH (carboxylated multi-walled carbon nantubes) adduct to mice during gestation and lactation period decreased the male offspring reproductive toxicity compared with those induced by BPA alone. The adduct decreased malondialdehyde (MDA) level in testis and follicle-stimulating hormone (FSH) in serum, but increased the level of serum testosterone in male offspring in comparison to BPA alone. Our investigations broadened the knowledge of nanotoxicity and provided important information on the safe application of CNTs.
doi_str_mv 10.3390/ijms150915981
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subjects Adsorption
Animals
Benzhydryl Compounds - chemistry
Benzhydryl Compounds - toxicity
Bisphenol A (BPA)
Body Weight - drug effects
Carbon
carbon nanotubes (CNTs)
contaminants adsorption
Endocrine disruptors
Endocrine Disruptors - chemistry
Endocrine Disruptors - toxicity
Endocrine system
environmental endocrine disrupting effect
Female
Follicle Stimulating Hormone - blood
Luteinizing Hormone - blood
Male
Malondialdehyde - analysis
Mice
Mice, Inbred ICR
Nanotubes
Nanotubes, Carbon - chemistry
Nanotubes, Carbon - toxicity
Phenols - chemistry
Phenols - toxicity
Reproduction - drug effects
reproductive toxicity
Rodents
Sex Ratio
Testosterone - blood
Water Pollutants, Chemical - chemistry
Water Pollutants, Chemical - toxicity
title Adsorption of bisphenol A to a carbon nanotube reduced its endocrine disrupting effect in mice male offspring
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