IgA Vasculitis: Etiology, Treatment, Biomarkers and Epigenetic Changes

IgA, previously called Henoch-Schönlein vasculitis, is an essential immune component that drives the host immune response to the external environment. As IgA has the unique characteristic of a flexible response to broad types of microorganisms, it sometimes causes an autoreactive response in the hos...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-07, Vol.22 (14), p.7538
Main Authors: Sugino, Hitomi, Sawada, Yu, Nakamura, Motonobu
Format: Article
Language:English
Subjects:
Antigens
Autoimmune diseases
Bacteria
biomarker
Biomarkers
COVID-19
Cytokines
Defense
epigenetic changes
Epigenetics
Etiology
Genes
Health risk assessment
IgA vasculitis
Immune response
Immune system
Immunoglobulin A
Immunoglobulins
Microorganisms
Pathogenesis
Pathogens
Polymorphism
Review
Schonlein-Henoch purpura
Signs and symptoms
treatment
Vasculitis
Viral infections
Viruses
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Summary:IgA, previously called Henoch-Schönlein vasculitis, is an essential immune component that drives the host immune response to the external environment. As IgA has the unique characteristic of a flexible response to broad types of microorganisms, it sometimes causes an autoreactive response in the host human body. IgA vasculitis and related organ dysfunction are representative IgA-mediated autoimmune diseases; bacterial and viral infections often trigger IgA vasculitis. Recent drug developments and the presence of COVID-19 have revealed that these agents can also trigger IgA vasculitis. These findings provide a novel understanding of the pathogenesis of IgA vasculitis. In this review, we focus on the characteristics of IgA and symptoms of IgA vasculitis and other organ dysfunction. We also mention the therapeutic approach, biomarkers, novel triggers for IgA vasculitis, and epigenetic modifications in patients with IgA vasculitis.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22147538