Inflammation as the nexus: exploring the link between acute myocardial infarction and chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD), particularly following acute exacerbations (AE-COPD), significantly heightens the risks and mortality associated with acute myocardial infarction (AMI). The intersection of COPD and AMI is characterised by a considerable overlap in inflammatory mechanism...

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Bibliographic Details
Published in:Frontiers in cardiovascular medicine 2024-02, Vol.11, p.1362564-1362564
Main Authors: Marriott, Eloise, Singanayagam, Aran, El-Awaisi, Juma
Format: Article
Language:English
Subjects:
acute myocardial infarction
anti-inflammatory
Cardiovascular Medicine
chronic obstructive pulmonary disease
inflammation
interleukins
S100A8/A9
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Summary:Chronic obstructive pulmonary disease (COPD), particularly following acute exacerbations (AE-COPD), significantly heightens the risks and mortality associated with acute myocardial infarction (AMI). The intersection of COPD and AMI is characterised by a considerable overlap in inflammatory mechanisms, which play a crucial role in the development of both conditions. Although extensive research has been conducted on individual inflammatory pathways in AMI and COPD, the understanding of thrombo-inflammatory crosstalk in comorbid settings remains limited. The effectiveness of various inflammatory components in reducing AMI infarct size or slowing COPD progression has shown promise, yet their efficacy in the context of comorbidity with COPD and AMI is not established. This review focuses on the critical importance of both local and systemic inflammation, highlighting it as a key pathophysiological connection between AMI and COPD/AE-COPD.
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2024.1362564