The roles of Th cells in myocardial infarction

Myocardial infarction, commonly known as a heart attack, is a serious condition caused by the abrupt stoppage of blood flow to a part of the heart, leading to tissue damage. A significant aspect of this condition is reperfusion injury, which occurs when blood flow is restored but exacerbates the dam...

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Bibliographic Details
Published in:Cell death discovery 2024-06, Vol.10 (1), p.287-16, Article 287
Main Authors: Liu, Jun, Liu, Feila, Liang, Tingting, Zhou, Yue, Su, Xiaohan, Li, Xue, Zeng, Jiao, Qu, Peng, Wang, Yali, Chen, Fuli, Lei, Qian, Li, Gang, Cheng, Panke
Format: Article
Language:English
Subjects:
692/420/256/2516
692/699/75/2/1674
Apoptosis
Biochemistry
Biomedical and Life Sciences
Blood flow
CD4 antigen
Cell Biology
Cell Cycle Analysis
Cytokines
Heart attacks
Helper cells
Immune response
Immune system
Innate immunity
Leukocytes (neutrophilic)
Life Sciences
Lymphocytes T
Macrophages
Myocardial infarction
Reperfusion
Review
Review Article
Stem Cells
γ-Interferon
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Summary:Myocardial infarction, commonly known as a heart attack, is a serious condition caused by the abrupt stoppage of blood flow to a part of the heart, leading to tissue damage. A significant aspect of this condition is reperfusion injury, which occurs when blood flow is restored but exacerbates the damage. This review first addresses the role of the innate immune system, including neutrophils and macrophages, in the cascade of events leading to myocardial infarction and reperfusion injury. It then shifts focus to the critical involvement of CD4+ T helper cells in these processes. These cells, pivotal in regulating the immune response and tissue recovery, include various subpopulations such as Th1, Th2, Th9, Th17, and Th22, each playing a unique role in the pathophysiology of myocardial infarction and reperfusion injury. These subpopulations contribute to the injury process through diverse mechanisms, with cytokines such as IFN-γ and IL-4 influencing the balance between tissue repair and injury exacerbation. Understanding the interplay between the innate immune system and CD4+ T helper cells, along with their cytokines, is crucial for developing targeted therapies to mitigate myocardial infarction and reperfusion injury, ultimately improving outcomes for cardiac patients.
ISSN:2058-7716
2058-7716
DOI:10.1038/s41420-024-02064-6