Associations of ARMS2 and CFH Gene Polymorphisms with Neovascular Age-Related Macular Degeneration

This study aimed to determine the association of A69S, del443ins54, and Y402H polymorphisms with neovascular age-related macular degeneration (nAMD) for the first time in an Indonesian population. Our case-control study involved 104 nAMD and 100 control subjects. AMD diagnosis was evaluated by retin...

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Bibliographic Details
Published in:Clinical ophthalmology (Auckland, N.Z.) N.Z.), 2021-01, Vol.15, p.1101-1108
Main Authors: Supanji, Supanji, Romdhoniyyah, Dewi Fathin, Sasongko, Muhammad Bayu, Agni, Angela Nurini, Wardhana, Firman Setya, Widayanti, Tri Wahyu, Prayogo, Muhammad Eko, Perdamaian, Ayudha Bahana Ilham, Dianratri, Aninditta, Kawaichi, Masashi, Oka, Chio
Format: Article
Language:English
Subjects:
Age
age-related macular degeneration
Analysis
arms2
cfh
Confidence intervals
Deoxyribonucleic acid
DNA
Ethylenediaminetetraacetic acid
Genes
Genetic aspects
Genetic polymorphisms
Genotype & phenotype
Hospitals
Hypertension
Macular degeneration
Original Research
Physiological aspects
Polymorphism
Public health
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Summary:This study aimed to determine the association of A69S, del443ins54, and Y402H polymorphisms with neovascular age-related macular degeneration (nAMD) for the first time in an Indonesian population. Our case-control study involved 104 nAMD and 100 control subjects. AMD diagnosis was evaluated by retinal specialists based on color fundus photography and optical coherence tomography. The polymorphisms on Y402H and A69S were analyzed by PCR-restriction fragment length polymorphism (PCR-RFLP), whereas del443ins54 was evaluated by PCR-based assay. Significant allelic associations with nAMD were detected on all polymorphisms (P
ISSN:1177-5467
1177-5483
1177-5483
DOI:10.2147/OPTH.S298310