Influence of Eu3+ Doping on Physiochemical Properties and Neuroprotective Potential of Polyacrylic Acid Functionalized Cerium Oxide Nanoparticles

Cerium oxide nanoparticles (CeONPs) exhibiting antioxidant properties are investigated as potential tools for neurodegenerative diseases. Here, we synthesized polyacrylic acid conjugated cerium oxide (CeO) nanoparticles, and further to enhance their neuroprotective effect, Eu3+ was substituted at di...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-02, Vol.25 (5), p.2501
Main Authors: Meenambal, Rugmani, Kruk, Tomasz, Jakubowska, Klaudia, Gurgul, Jacek, Szczepanowicz, Krzysztof, Szczęch, Marta, Szyk-Warszyńska, Lilianna, Warszyński, Piotr, Jantas, Danuta
Format: Article
Language:English
Subjects:
Acids
Antioxidants
cerium oxide
Cerium oxides
Charged particles
europium
Microscopy
Nanoparticles
neuroprotection
Oxidative stress
Precision medicine
Spectrum analysis
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Summary:Cerium oxide nanoparticles (CeONPs) exhibiting antioxidant properties are investigated as potential tools for neurodegenerative diseases. Here, we synthesized polyacrylic acid conjugated cerium oxide (CeO) nanoparticles, and further to enhance their neuroprotective effect, Eu3+ was substituted at different concentrations (5, 10, 15 and 20 mol%) to the CeO, which can also impart fluorescence to the system. CeONPs and Eu-CeONPs in the size range of 15–30 nm were stable at room temperature. The X-ray Photoelectron Spectroscopy (XPS) analysis revealed the chemical state of Eu and Ce components, and we could conclude that all Eu3+ detected on the surface is well integrated into the cerium oxide lattice. The emission spectrum of Eu-CeO arising from the 7F0 → 5D1 MD and 7F0 → 5D2 transitions indicated the Eu3+ ion acting as a luminescence center. The fluorescence of Eu-CeONPs was visualized by depositing them at the surface of positively charged latex particles. The developed nanoparticles were safe for human neuronal-like cells. Compared with CeONPs, Eu-CeONPs at all concentrations exhibited enhanced neuroprotection against 6-OHDA, while the protection trend of Eu-CeO was similar to that of CeO against H2O2 in SH-SY5Y cells. Hence, the developed Eu-CeONPs could be further investigated as a potential theranostic probe.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25052501