The Role of Stellate Cells in Pancreatic Ductal Adenocarcinoma: Targeting Perspectives

Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal clinical outcome. Accumulating evidence suggests that activated pancreatic stellate cells (PSCs), the major producers of extracellular matrix (ECM), drive the severe stromal/desmoplastic reaction in PDAC. Furtherm...

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Bibliographic Details
Published in:Frontiers in oncology 2021-01, Vol.10, p.621937-621937
Main Authors: Wu, Yang, Zhang, Chun, Jiang, Kuirong, Werner, Jens, Bazhin, Alexandr V, D'Haese, Jan G
Format: Article
Language:English
Subjects:
Oncology
pancreatic ductal adenocarcinoma
pancreatic stellate cells
stroma-targeting strategy
tumor microenvironment
tumor therapy
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Summary:Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal clinical outcome. Accumulating evidence suggests that activated pancreatic stellate cells (PSCs), the major producers of extracellular matrix (ECM), drive the severe stromal/desmoplastic reaction in PDAC. Furthermore, the crosstalk among PSCs, pancreatic cancer cells (PCCs) as well as other stroma cells can establish a growth-supportive tumor microenvironment (TME) of PDAC, thereby enhancing tumor growth, metastasis, and chemoresistance various pathways. Recently, targeting stroma has emerged as a promising strategy for PDAC therapy, and several novel strategies have been proposed. The aim of our study is to give a profound review of the role of PSCs in PDAC progression and recent advances in stroma-targeting strategies.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2020.621937