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Development of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis

Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a promising approach with a high optimization potential for the treatment of peritoneal carcinomatosis. To study the efficacy of PIPAC and drugs, first rodent cancer models were developed. But inefficient drug aerosol supply and knowledge g...

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Published in:Scientific reports 2021-11, Vol.11 (1), p.21843-21843, Article 21843
Main Authors: Göhler, Daniel, Geldner, Antje, Gritzki, Ralf, Lohse, Franz, Große, Stephan, Sobilo, Julien, Felsmann, Clemens, Buggisch, Jonathan R., Le Pape, Alain, Rudolph, Andreas, Stintz, Michael, Giger-Pabst, Urs
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creator Göhler, Daniel
Geldner, Antje
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Stintz, Michael
Giger-Pabst, Urs
description Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a promising approach with a high optimization potential for the treatment of peritoneal carcinomatosis. To study the efficacy of PIPAC and drugs, first rodent cancer models were developed. But inefficient drug aerosol supply and knowledge gaps concerning spatial drug distribution can limit the results based on such models. To study drug aerosol supply/deposition, computed tomography scans of a rat capnoperitoneum were used to deduce a virtual and a physical phantom of the rat capnoperitoneum (RCP). RCP qualification was performed for a specific PIPAC method, where the capnoperitoneum is continuously purged by the drug aerosol. In this context, also in-silico analyses by computational fluid dynamic modelling were conducted on the virtual RCP. The physical RCP was used for ex-vivo granulometric analyses concerning drug deposition. Results of RCP qualification show that aerosol deposition in a continuous purged rat capnoperitoneum depends strongly on the position of the inlet and outlet port. Moreover, it could be shown that the droplet size and charge condition of the drug aerosol define the deposition efficiency. In summary, the developed virtual and physical RCP enables detailed in-silico and ex-vivo analyses on drug supply/deposition in rodents.
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subjects 631/67/1059
631/67/1059/153
639/166/985
639/301/930/12
639/766/189
639/766/419/1131
692/308/1426
Aerosols
Animal models
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - pharmacokinetics
Chemotherapy
Computed tomography
Computer applications
Computer Simulation
Computer-Aided Design
Gastric cancer
Humanities and Social Sciences
Humans
Hydrodynamics
Injections, Intraperitoneal - instrumentation
Injections, Intraperitoneal - methods
Models, Animal
multidisciplinary
Peritoneal Neoplasms - diagnostic imaging
Peritoneal Neoplasms - drug therapy
Peritoneal Neoplasms - metabolism
Peritoneum
Peritoneum - diagnostic imaging
Peritoneum - metabolism
Phantoms, Imaging
Pressure
Rats
Rodents
Science
Science (multidisciplinary)
Tomography, X-Ray Computed
User-Computer Interface
title Development of a rat capnoperitoneum phantom to study drug aerosol deposition in the context of anticancer research on peritoneal carcinomatosis
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