Aspersymmetide A, a New Centrosymmetric Cyclohexapeptide from the Marine-Derived Fungus Aspergillus versicolor

A new centrosymmetric cyclohexapeptide, aspersymmetide A ( ), together with a known peptide, asperphenamate ( ), was isolated from the fungus isolated from a gorgonian coral sp., collected from the South China Sea. The chemical structure of was elucidated by analyzing its NMR spectroscopy and MS spe...

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Bibliographic Details
Published in:Marine drugs 2017-11, Vol.15 (11), p.363
Main Authors: Hou, Xue-Mei, Zhang, Ya-Hui, Hai, Yang, Zheng, Ji-Yong, Gu, Yu-Cheng, Wang, Chang-Yun, Shao, Chang-Lun
Format: Article
Language:English
Subjects:
Amino acids
Analytical methods
Animals
Anthozoa - microbiology
Aspergillus - chemistry
Aspergillus versicolor
Carijoa sp
Cell Line, Tumor
Cell lines
centrosymmetric cyclohexapeptide
China
Corals
Cytotoxicity
Fungal Proteins - chemistry
Fungi
gorgonian-derived fungus
Humans
Magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy - methods
Marine Biology - methods
Marine invertebrates
MCF-7 Cells
NMR
NMR spectroscopy
Nuclear magnetic resonance
Short Note
Spectrometry
Toxicity
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Summary:A new centrosymmetric cyclohexapeptide, aspersymmetide A ( ), together with a known peptide, asperphenamate ( ), was isolated from the fungus isolated from a gorgonian coral sp., collected from the South China Sea. The chemical structure of was elucidated by analyzing its NMR spectroscopy and MS spectrometry data, and the absolute configurations of the amino acids of were determined by Marfey's method and UPLC-MS analysis of the hydrolysate. Aspersymmetide A ( ) represents the first example of marine-derived centrosymmetric cyclohexapeptide. Moreover, exhibited weak cytotoxicity against NCI-H292 and A431 cell lines at the concentration of 10 μM.
ISSN:1660-3397
1660-3397
DOI:10.3390/md15110363