Imatinib associated temporal bone osteonecrosis

Key Clinical Message Tyrosine kinase inhibitors have substantially improved survival in patients with gastrointestinal stromal tumors (GIST) and chronic myeloid leukemia (CML). We report the first association between long‐term imatinib use and temporal bone osteonecrosis, highlighting the importance...

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Bibliographic Details
Published in:Clinical case reports 2023-07, Vol.11 (7), p.e7611-n/a
Main Authors: McKenna, Dominic, Reddy, Ekambar
Format: Article
Language:English
Subjects:
Bones
Case Image
Case Images
chronic infection
CML
Consent
Debridement
ear canal
ear discharge
ear pain
erosion
Gastrointestinal cancer
GIST
Hematology
imatinib
Medical imaging
Necrosis
osteonecrosis
otalgia
otology
otorrhea
temporal bone
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Summary:Key Clinical Message Tyrosine kinase inhibitors have substantially improved survival in patients with gastrointestinal stromal tumors (GIST) and chronic myeloid leukemia (CML). We report the first association between long‐term imatinib use and temporal bone osteonecrosis, highlighting the importance of prompt ENT evaluation of such patients with new otological symptoms. Novel association between imatinib use and external auditory canal bony erosion.
ISSN:2050-0904
2050-0904
DOI:10.1002/ccr3.7611