Clinical study on autosomal dominant polycystic kidney disease among North Tunisians

Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease, which usually manifests in adulthood. It is characterized by the develop- ment of multiple cysts in the kidneys and many other extrarenal manifestations. We aimed to determine the factors that contribut...

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Bibliographic Details
Published in:Saudi journal of kidney diseases and transplantation 2019, Vol.30 (1), p.175-184
Main Authors: Gorsane, Iman, Bin Hamidah, Fathi, Qushah, Rim, Hajji, Maryam, Barbush, Samiyah, Bin Abd Allah, Tayyib, Karud, Hayah, Haydari, Hafiz, Hirz Allah, Amal, Abd al-Rahim, Izz al-Din
Format: Article
Language:English
Subjects:
Adult
Age
Care and treatment
Chronic kidney failure
Clinical trials
Cysts
Diagnosis
Family medical history
Female
Health aspects
Hemodialysis
Hemorrhage
Humans
Hypertension
Kidney diseases
Male
Medical prognosis
Medical research
Middle Aged
Mortality
Patients
Polycystic kidney disease
Polycystic Kidney, Autosomal Dominant - diagnosis
Polycystic Kidney, Autosomal Dominant - epidemiology
Polycystic Kidney, Autosomal Dominant - mortality
Polycystic Kidney, Autosomal Dominant - physiopathology
Prognosis
Renal replacement therapy
Retrospective Studies
Risk Factors
Tolvaptan
Transplants & implants
Tunisia - epidemiology
Tunisians
مرض الكلى المتعدد الكيسات
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Summary:Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease, which usually manifests in adulthood. It is characterized by the develop- ment of multiple cysts in the kidneys and many other extrarenal manifestations. We aimed to determine the factors that contribute to the progression of ADPKD to end-stage renal disease (ESRD). In a retrospective multicentric study, we reviewed the records of 569 patients with ADPKD, hospitalized at a nephrology department or followed up at the outpatient department of university and regional hospitals, covering the north and center of the country, during the period 1969–2016. The mean age of the study patients was 48.54 ± 13.68 years and 14% were young adults (40 years (P = 0.009), hematuria (P = 0.034), hemoglobin >14 g/dL (P = 0.0013), high uric acid level (P = 0.001), and leukocyturia (P = 0.02). Death occurred in 59 cases (10.3%), mostly
ISSN:1319-2442
2320-3838
DOI:10.4103/1319-2442.252908