Altered brain functional network connectivity and topology in type 2 diabetes mellitus

Introduction: Type 2 diabetes mellitus (T2DM) accelerates brain aging and disrupts brain functional network connectivity, though the specific mechanisms remain unclear. This study aimed to investigate T2DM-driven alterations in brain functional network connectivity and topology.

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Bibliographic Details
Published in:Frontiers in neuroscience 2025-01, Vol.19
Main Authors: Ni, Weiwei, Liu, Weiyin Vivian, Li, Mingrui, Wei, Shouchao, Xu, Xuanzi, Huang, Shutong, Zhu, Lanhui, Wang, Jieru, Wen, Fengling, Zhou, Hailing
Format: Article
Language:English
Subjects:
blood oxygenation level-dependent imaging
Blood pressure
Brain
brain functional network connectivity
Cognitive ability
Diabetes
Diabetes mellitus (non-insulin dependent)
Disease
functional magnetic resonance imaging
Glucose
graph theory
Hemoglobin
Hyperglycemia
Magnetic resonance imaging
Medical imaging
Mental disorders
Neural networks
Neuroimaging
Neuropsychology
Professional practice
type 2 diabetes mellitus
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Description
Summary:Introduction: Type 2 diabetes mellitus (T2DM) accelerates brain aging and disrupts brain functional network connectivity, though the specific mechanisms remain unclear. This study aimed to investigate T2DM-driven alterations in brain functional network connectivity and topology.
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2025.1472010