Catechol-O-methyl transferase suppresses cell invasion and interplays with MET signaling in estrogen dependent breast cancer

Catechol-O-methyl transferase (COMT) is involved in detoxification of catechol estrogens, playing cancer-protective role in cells producing or utilizing estrogen. Moreover, COMT suppressed migration potential of breast cancer (BC) cells. To delineate COMT role in metastasis of estrogen receptor (ER)...

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Bibliographic Details
Published in:Scientific reports 2023-01, Vol.13 (1), p.1285-1285, Article 1285
Main Authors: Janacova, Lucia, Stenckova, Michaela, Lapcik, Petr, Hrachovinova, Sarka, Bouchalova, Pavla, Potesil, David, Hrstka, Roman, Müller, Petr, Bouchal, Pavel
Format: Article
Language:English
Subjects:
631/45/475
631/45/475/2290
631/45/500
631/67/1347
631/80/84/2336
Breast cancer
Catechol
Catechol O-Methyltransferase - genetics
Catechols
Detoxification
Estrogen receptors
Estrogens
Estrogens - metabolism
Estrogens, Catechol
Humanities and Social Sciences
Metastases
multidisciplinary
Neoplasms
Phenotypes
Proteinase inhibitors
Proteomes
Proteomics
Receptors, Estrogen - metabolism
Science
Science (multidisciplinary)
Tandem Mass Spectrometry
Transcriptomes
Tumor suppressor genes
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Summary:Catechol-O-methyl transferase (COMT) is involved in detoxification of catechol estrogens, playing cancer-protective role in cells producing or utilizing estrogen. Moreover, COMT suppressed migration potential of breast cancer (BC) cells. To delineate COMT role in metastasis of estrogen receptor (ER) dependent BC, we investigated the effect of COMT overexpression on invasion, transcriptome, proteome and interactome of MCF7 cells, a luminal A BC model, stably transduced with lentiviral vector carrying COMT gene (MCF7-COMT). 2D and 3D assays revealed that COMT overexpression associates with decreased cell invasion ( p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-28078-1