Gold Nanoparticles for Targeting Varlitinib to Human Pancreatic Cancer Cells

Colloidal gold nanoparticles are targeting probes to improve varlitinib delivery into cancer cells. The nanoconjugates were designed by the bioconjugation of pegylated gold nanoparticles with varlitinib via carbodiimide-mediated cross-linking and characterized by infrared and X-ray photoelectron spe...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutics 2018-07, Vol.10 (3), p.91
Main Authors: Coelho, Sílvia Castro, Reis, Daniel Pires, Pereira, Maria Carmo, Coelho, Manuel A N
Format: Article
Language:English
Subjects:
gold nanoparticles
pancreatic cells
tyrosine conjugation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Colloidal gold nanoparticles are targeting probes to improve varlitinib delivery into cancer cells. The nanoconjugates were designed by the bioconjugation of pegylated gold nanoparticles with varlitinib via carbodiimide-mediated cross-linking and characterized by infrared and X-ray photoelectron spectroscopy. The drug release response shows an initial delay and a complete drug release after 72 h is detected. In vitro experiments with MIA PaCa-2 cells corroborate that PEGAuNPsVarl conjugates increase the varlitinib toxic effect at very low concentrations (IC50 = 80 nM) if compared with varlitinib alone (IC50 = 259 nM). Our results acknowledge a decrease of drug side effects in normal cells and an enhancement of drug efficacy against to the pancreatic cancer cells reported.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics10030091