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Surgical Site Infection after Primary Open Surgery for Laryngeal Cancer in a Tertiary Hospital in Belgrade, Serbia: A 10-Year Prospective Cohort Study
Surgical site infection (SSI) in laryngeal cancer (LC) patients significantly increases morbidity and may postpone adjuvant therapy. Additionally, SSI can prolong hospitalization, thus representing a burden for the healthcare system. Most of the published studies refer to SSI after salvage laryngect...
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Published in: | Antibiotics (Basel) 2024-09, Vol.13 (10), p.918 |
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creator | Sotirović, Jelena Rančić, Nemanja Pavićević, Ljubomir Baletić, Nenad Dimić, Aleksandar Čukić, Ognjen Perić, Aleksandar Milojević, Milanko Ljubenović, Nenad Milošević, Darko Šuljagić, Vesna |
description | Surgical site infection (SSI) in laryngeal cancer (LC) patients significantly increases morbidity and may postpone adjuvant therapy. Additionally, SSI can prolong hospitalization, thus representing a burden for the healthcare system. Most of the published studies refer to SSI after salvage laryngectomy.
The present prospective cohort study aimed to clarify the incidence and factors associated with SSI in patients after primary open surgery for LC. Through regular hospital surveillance of patients who underwent primary partial or total laryngectomy, we gathered 24 putative factors and identified SSI from 2013 to 2022. Patients with SSI were compared with patients without SSI.
SSI was observed in 21 (6.6%) of 319 patients. ULRA showed that the occurrence of SSI was significantly associated with the American Society of Anesthesiologists (ASA) score, other postoperative healthcare-associated (HAI) infection, T classification, N classification, advanced clinical stage (III-IV), length of stay (LOS), duration of drainage, and the National Healthcare Safety Network (NHSN) risk index. Multivariate logistic regression analysis identified two independent factors associated with SSI occurring in these patients: duration of drainage (RR (relative risk) 1.593; 95% CI 1.159-2.189;
= 0.004) and LOS (RR: 1.074; 95% CI: 1.037-1.112;
< 0.001).
Our study provided insight into the burden of SSI in LC patients, highlighting several priority areas and targets for quality improvement. |
doi_str_mv | 10.3390/antibiotics13100918 |
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The present prospective cohort study aimed to clarify the incidence and factors associated with SSI in patients after primary open surgery for LC. Through regular hospital surveillance of patients who underwent primary partial or total laryngectomy, we gathered 24 putative factors and identified SSI from 2013 to 2022. Patients with SSI were compared with patients without SSI.
SSI was observed in 21 (6.6%) of 319 patients. ULRA showed that the occurrence of SSI was significantly associated with the American Society of Anesthesiologists (ASA) score, other postoperative healthcare-associated (HAI) infection, T classification, N classification, advanced clinical stage (III-IV), length of stay (LOS), duration of drainage, and the National Healthcare Safety Network (NHSN) risk index. Multivariate logistic regression analysis identified two independent factors associated with SSI occurring in these patients: duration of drainage (RR (relative risk) 1.593; 95% CI 1.159-2.189;
= 0.004) and LOS (RR: 1.074; 95% CI: 1.037-1.112;
< 0.001).
Our study provided insight into the burden of SSI in LC patients, highlighting several priority areas and targets for quality improvement.</description><identifier>ISSN: 2079-6382</identifier><identifier>EISSN: 2079-6382</identifier><identifier>DOI: 10.3390/antibiotics13100918</identifier><identifier>PMID: 39452185</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adjuvant treatment ; antibiotic prophylaxis ; Antibiotics ; Cancer ; Cancer surgery ; Cancer therapies ; Care and treatment ; Catheters ; Chemotherapy ; Classification ; Comparative analysis ; Diabetes ; Disease prevention ; Gram-negative bacteria ; Head & neck cancer ; Health aspects ; Health care ; Health care policy ; Hospitals ; Infection ; Laboratories ; Laryngeal cancer ; Larynx ; Length of stay ; Medical societies ; Metronidazole ; Microorganisms ; Morbidity ; Mortality ; Patient safety ; Patients ; Quality control ; Radiation therapy ; Regression analysis ; Risk factors ; Sociodemographics ; Surgeons ; Surgery ; Surgical drains ; Surgical outcomes ; surgical site infection ; Surgical site infections ; Wound drainage</subject><ispartof>Antibiotics (Basel), 2024-09, Vol.13 (10), p.918</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c402t-d15f01fa9ae8e585e0ff88732ede69dad108bd345f5b7915c6cd563fcc57be673</cites><orcidid>0000-0001-9818-0668 ; 0000-0003-2830-0673 ; 0000-0001-7047-0428 ; 0000-0002-7915-0815 ; 0000-0002-8453-7272 ; 0000-0002-5122-8094</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3120508187/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3120508187?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39452185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sotirović, Jelena</creatorcontrib><creatorcontrib>Rančić, Nemanja</creatorcontrib><creatorcontrib>Pavićević, Ljubomir</creatorcontrib><creatorcontrib>Baletić, Nenad</creatorcontrib><creatorcontrib>Dimić, Aleksandar</creatorcontrib><creatorcontrib>Čukić, Ognjen</creatorcontrib><creatorcontrib>Perić, Aleksandar</creatorcontrib><creatorcontrib>Milojević, Milanko</creatorcontrib><creatorcontrib>Ljubenović, Nenad</creatorcontrib><creatorcontrib>Milošević, Darko</creatorcontrib><creatorcontrib>Šuljagić, Vesna</creatorcontrib><title>Surgical Site Infection after Primary Open Surgery for Laryngeal Cancer in a Tertiary Hospital in Belgrade, Serbia: A 10-Year Prospective Cohort Study</title><title>Antibiotics (Basel)</title><addtitle>Antibiotics (Basel)</addtitle><description>Surgical site infection (SSI) in laryngeal cancer (LC) patients significantly increases morbidity and may postpone adjuvant therapy. Additionally, SSI can prolong hospitalization, thus representing a burden for the healthcare system. Most of the published studies refer to SSI after salvage laryngectomy.
The present prospective cohort study aimed to clarify the incidence and factors associated with SSI in patients after primary open surgery for LC. Through regular hospital surveillance of patients who underwent primary partial or total laryngectomy, we gathered 24 putative factors and identified SSI from 2013 to 2022. Patients with SSI were compared with patients without SSI.
SSI was observed in 21 (6.6%) of 319 patients. ULRA showed that the occurrence of SSI was significantly associated with the American Society of Anesthesiologists (ASA) score, other postoperative healthcare-associated (HAI) infection, T classification, N classification, advanced clinical stage (III-IV), length of stay (LOS), duration of drainage, and the National Healthcare Safety Network (NHSN) risk index. Multivariate logistic regression analysis identified two independent factors associated with SSI occurring in these patients: duration of drainage (RR (relative risk) 1.593; 95% CI 1.159-2.189;
= 0.004) and LOS (RR: 1.074; 95% CI: 1.037-1.112;
< 0.001).
Our study provided insight into the burden of SSI in LC patients, highlighting several priority areas and targets for quality improvement.</description><subject>Adjuvant treatment</subject><subject>antibiotic prophylaxis</subject><subject>Antibiotics</subject><subject>Cancer</subject><subject>Cancer surgery</subject><subject>Cancer therapies</subject><subject>Care and treatment</subject><subject>Catheters</subject><subject>Chemotherapy</subject><subject>Classification</subject><subject>Comparative analysis</subject><subject>Diabetes</subject><subject>Disease prevention</subject><subject>Gram-negative bacteria</subject><subject>Head & neck cancer</subject><subject>Health aspects</subject><subject>Health care</subject><subject>Health care policy</subject><subject>Hospitals</subject><subject>Infection</subject><subject>Laboratories</subject><subject>Laryngeal cancer</subject><subject>Larynx</subject><subject>Length of stay</subject><subject>Medical societies</subject><subject>Metronidazole</subject><subject>Microorganisms</subject><subject>Morbidity</subject><subject>Mortality</subject><subject>Patient safety</subject><subject>Patients</subject><subject>Quality control</subject><subject>Radiation therapy</subject><subject>Regression analysis</subject><subject>Risk factors</subject><subject>Sociodemographics</subject><subject>Surgeons</subject><subject>Surgery</subject><subject>Surgical drains</subject><subject>Surgical outcomes</subject><subject>surgical site infection</subject><subject>Surgical site infections</subject><subject>Wound drainage</subject><issn>2079-6382</issn><issn>2079-6382</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptktFuFCEUhidGY5u1T2BiSLzxwq0wDDPgjdlu1G6ySU22XnhFGDhM2czCyjBN-iI-r4xba9c0XACH7__JD6coXhN8TqnAH5RPrnUhOT0QSjAWhD8rTkvciHlNefn80fqkOBuGLcYTRDnmL4sTKipWEs5Oi1-bMXZOqx5tXAK08hZ0csEjZRNE9C26nYp36GoPHk0o5I0NEa1z1XeQdUvldSZdlqBriMlN_GUY9i7l01y-gL6LysB7tIHYOvURLRDB8x-gJv8MTjfeAlqGmxAT2qTR3L0qXljVD3B2P8-K718-Xy8v5-urr6vlYj3XFS7T3BBmMbFKKODAOANsLecNLcFALYwyBPPW0IpZ1jaCMF1rw2pqtWZNC3VDZ8Xq4GuC2sr9Ia0Mysk_hRA7qXIk3YNsiWkqJuqqVbaigrSCYqWbkrCqMazl2evTwWs_tjswGnyKqj8yPT7x7kZ24VYSwjArS5wd3t07xPBzhCHJnRs09L3yEMZBUlJiJjjPEWbF2__QbRijz291oDAnvPlHdSoncN6GfLGeTOWCkyp3Q4nLTJ0_QeVhYOd08GBdrh8J6EGg8_cNEexDSILl1J7yifbMqjeP3-dB87cZ6W_hfOMF</recordid><startdate>20240925</startdate><enddate>20240925</enddate><creator>Sotirović, Jelena</creator><creator>Rančić, Nemanja</creator><creator>Pavićević, Ljubomir</creator><creator>Baletić, Nenad</creator><creator>Dimić, Aleksandar</creator><creator>Čukić, Ognjen</creator><creator>Perić, Aleksandar</creator><creator>Milojević, Milanko</creator><creator>Ljubenović, Nenad</creator><creator>Milošević, Darko</creator><creator>Šuljagić, Vesna</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-9818-0668</orcidid><orcidid>https://orcid.org/0000-0003-2830-0673</orcidid><orcidid>https://orcid.org/0000-0001-7047-0428</orcidid><orcidid>https://orcid.org/0000-0002-7915-0815</orcidid><orcidid>https://orcid.org/0000-0002-8453-7272</orcidid><orcidid>https://orcid.org/0000-0002-5122-8094</orcidid></search><sort><creationdate>20240925</creationdate><title>Surgical Site Infection after Primary Open Surgery for Laryngeal Cancer in a Tertiary Hospital in Belgrade, Serbia: A 10-Year Prospective Cohort Study</title><author>Sotirović, Jelena ; Rančić, Nemanja ; Pavićević, Ljubomir ; Baletić, Nenad ; Dimić, Aleksandar ; Čukić, Ognjen ; Perić, Aleksandar ; Milojević, Milanko ; Ljubenović, Nenad ; Milošević, Darko ; Šuljagić, Vesna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-d15f01fa9ae8e585e0ff88732ede69dad108bd345f5b7915c6cd563fcc57be673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adjuvant treatment</topic><topic>antibiotic prophylaxis</topic><topic>Antibiotics</topic><topic>Cancer</topic><topic>Cancer surgery</topic><topic>Cancer therapies</topic><topic>Care and treatment</topic><topic>Catheters</topic><topic>Chemotherapy</topic><topic>Classification</topic><topic>Comparative analysis</topic><topic>Diabetes</topic><topic>Disease prevention</topic><topic>Gram-negative bacteria</topic><topic>Head & neck cancer</topic><topic>Health aspects</topic><topic>Health care</topic><topic>Health care policy</topic><topic>Hospitals</topic><topic>Infection</topic><topic>Laboratories</topic><topic>Laryngeal cancer</topic><topic>Larynx</topic><topic>Length of stay</topic><topic>Medical societies</topic><topic>Metronidazole</topic><topic>Microorganisms</topic><topic>Morbidity</topic><topic>Mortality</topic><topic>Patient safety</topic><topic>Patients</topic><topic>Quality control</topic><topic>Radiation therapy</topic><topic>Regression analysis</topic><topic>Risk factors</topic><topic>Sociodemographics</topic><topic>Surgeons</topic><topic>Surgery</topic><topic>Surgical drains</topic><topic>Surgical outcomes</topic><topic>surgical site infection</topic><topic>Surgical site infections</topic><topic>Wound drainage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sotirović, Jelena</creatorcontrib><creatorcontrib>Rančić, Nemanja</creatorcontrib><creatorcontrib>Pavićević, Ljubomir</creatorcontrib><creatorcontrib>Baletić, Nenad</creatorcontrib><creatorcontrib>Dimić, Aleksandar</creatorcontrib><creatorcontrib>Čukić, Ognjen</creatorcontrib><creatorcontrib>Perić, Aleksandar</creatorcontrib><creatorcontrib>Milojević, Milanko</creatorcontrib><creatorcontrib>Ljubenović, Nenad</creatorcontrib><creatorcontrib>Milošević, Darko</creatorcontrib><creatorcontrib>Šuljagić, Vesna</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Biological Sciences</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Antibiotics (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sotirović, Jelena</au><au>Rančić, Nemanja</au><au>Pavićević, Ljubomir</au><au>Baletić, Nenad</au><au>Dimić, Aleksandar</au><au>Čukić, Ognjen</au><au>Perić, Aleksandar</au><au>Milojević, Milanko</au><au>Ljubenović, Nenad</au><au>Milošević, Darko</au><au>Šuljagić, Vesna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Surgical Site Infection after Primary Open Surgery for Laryngeal Cancer in a Tertiary Hospital in Belgrade, Serbia: A 10-Year Prospective Cohort Study</atitle><jtitle>Antibiotics (Basel)</jtitle><addtitle>Antibiotics (Basel)</addtitle><date>2024-09-25</date><risdate>2024</risdate><volume>13</volume><issue>10</issue><spage>918</spage><pages>918-</pages><issn>2079-6382</issn><eissn>2079-6382</eissn><abstract>Surgical site infection (SSI) in laryngeal cancer (LC) patients significantly increases morbidity and may postpone adjuvant therapy. Additionally, SSI can prolong hospitalization, thus representing a burden for the healthcare system. Most of the published studies refer to SSI after salvage laryngectomy.
The present prospective cohort study aimed to clarify the incidence and factors associated with SSI in patients after primary open surgery for LC. Through regular hospital surveillance of patients who underwent primary partial or total laryngectomy, we gathered 24 putative factors and identified SSI from 2013 to 2022. Patients with SSI were compared with patients without SSI.
SSI was observed in 21 (6.6%) of 319 patients. ULRA showed that the occurrence of SSI was significantly associated with the American Society of Anesthesiologists (ASA) score, other postoperative healthcare-associated (HAI) infection, T classification, N classification, advanced clinical stage (III-IV), length of stay (LOS), duration of drainage, and the National Healthcare Safety Network (NHSN) risk index. Multivariate logistic regression analysis identified two independent factors associated with SSI occurring in these patients: duration of drainage (RR (relative risk) 1.593; 95% CI 1.159-2.189;
= 0.004) and LOS (RR: 1.074; 95% CI: 1.037-1.112;
< 0.001).
Our study provided insight into the burden of SSI in LC patients, highlighting several priority areas and targets for quality improvement.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39452185</pmid><doi>10.3390/antibiotics13100918</doi><orcidid>https://orcid.org/0000-0001-9818-0668</orcidid><orcidid>https://orcid.org/0000-0003-2830-0673</orcidid><orcidid>https://orcid.org/0000-0001-7047-0428</orcidid><orcidid>https://orcid.org/0000-0002-7915-0815</orcidid><orcidid>https://orcid.org/0000-0002-8453-7272</orcidid><orcidid>https://orcid.org/0000-0002-5122-8094</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adjuvant treatment antibiotic prophylaxis Antibiotics Cancer Cancer surgery Cancer therapies Care and treatment Catheters Chemotherapy Classification Comparative analysis Diabetes Disease prevention Gram-negative bacteria Head & neck cancer Health aspects Health care Health care policy Hospitals Infection Laboratories Laryngeal cancer Larynx Length of stay Medical societies Metronidazole Microorganisms Morbidity Mortality Patient safety Patients Quality control Radiation therapy Regression analysis Risk factors Sociodemographics Surgeons Surgery Surgical drains Surgical outcomes surgical site infection Surgical site infections Wound drainage |
title | Surgical Site Infection after Primary Open Surgery for Laryngeal Cancer in a Tertiary Hospital in Belgrade, Serbia: A 10-Year Prospective Cohort Study |
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