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Surgical Site Infection after Primary Open Surgery for Laryngeal Cancer in a Tertiary Hospital in Belgrade, Serbia: A 10-Year Prospective Cohort Study

Surgical site infection (SSI) in laryngeal cancer (LC) patients significantly increases morbidity and may postpone adjuvant therapy. Additionally, SSI can prolong hospitalization, thus representing a burden for the healthcare system. Most of the published studies refer to SSI after salvage laryngect...

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Published in:Antibiotics (Basel) 2024-09, Vol.13 (10), p.918
Main Authors: Sotirović, Jelena, Rančić, Nemanja, Pavićević, Ljubomir, Baletić, Nenad, Dimić, Aleksandar, Čukić, Ognjen, Perić, Aleksandar, Milojević, Milanko, Ljubenović, Nenad, Milošević, Darko, Šuljagić, Vesna
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container_title Antibiotics (Basel)
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creator Sotirović, Jelena
Rančić, Nemanja
Pavićević, Ljubomir
Baletić, Nenad
Dimić, Aleksandar
Čukić, Ognjen
Perić, Aleksandar
Milojević, Milanko
Ljubenović, Nenad
Milošević, Darko
Šuljagić, Vesna
description Surgical site infection (SSI) in laryngeal cancer (LC) patients significantly increases morbidity and may postpone adjuvant therapy. Additionally, SSI can prolong hospitalization, thus representing a burden for the healthcare system. Most of the published studies refer to SSI after salvage laryngectomy. The present prospective cohort study aimed to clarify the incidence and factors associated with SSI in patients after primary open surgery for LC. Through regular hospital surveillance of patients who underwent primary partial or total laryngectomy, we gathered 24 putative factors and identified SSI from 2013 to 2022. Patients with SSI were compared with patients without SSI. SSI was observed in 21 (6.6%) of 319 patients. ULRA showed that the occurrence of SSI was significantly associated with the American Society of Anesthesiologists (ASA) score, other postoperative healthcare-associated (HAI) infection, T classification, N classification, advanced clinical stage (III-IV), length of stay (LOS), duration of drainage, and the National Healthcare Safety Network (NHSN) risk index. Multivariate logistic regression analysis identified two independent factors associated with SSI occurring in these patients: duration of drainage (RR (relative risk) 1.593; 95% CI 1.159-2.189; = 0.004) and LOS (RR: 1.074; 95% CI: 1.037-1.112; < 0.001). Our study provided insight into the burden of SSI in LC patients, highlighting several priority areas and targets for quality improvement.
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subjects Adjuvant treatment
antibiotic prophylaxis
Antibiotics
Cancer
Cancer surgery
Cancer therapies
Care and treatment
Catheters
Chemotherapy
Classification
Comparative analysis
Diabetes
Disease prevention
Gram-negative bacteria
Head & neck cancer
Health aspects
Health care
Health care policy
Hospitals
Infection
Laboratories
Laryngeal cancer
Larynx
Length of stay
Medical societies
Metronidazole
Microorganisms
Morbidity
Mortality
Patient safety
Patients
Quality control
Radiation therapy
Regression analysis
Risk factors
Sociodemographics
Surgeons
Surgery
Surgical drains
Surgical outcomes
surgical site infection
Surgical site infections
Wound drainage
title Surgical Site Infection after Primary Open Surgery for Laryngeal Cancer in a Tertiary Hospital in Belgrade, Serbia: A 10-Year Prospective Cohort Study
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