Prevalence of Epidermal Growth Factor Receptor Mutations in Patients with Non-Small Cell Lung Cancer in Turkish Population

mutation analysis in non-small cell lung cancer is important for selecting patients who will receive treatment with tyrosine kinase inhibitors. In this study, we aimed to investigate the prevalence of epidermal growth factor receptor mutations and mutation patterns in the Turkish population. We retr...

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Bibliographic Details
Published in:Balkan medical journal 2017-12, Vol.34 (6), p.567-571
Main Authors: Tezel, Gaye Guler, Sener, Ebru, Aydin, Cisel, Onder, Sevgen
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Analysis
Antineoplastic Agents - therapeutic use
Brief Report
Carcinoma, Non-Small-Cell Lung - drug therapy
Carcinoma, Non-Small-Cell Lung - epidemiology
Carcinoma, Non-Small-Cell Lung - genetics
Care and treatment
DNA Mutational Analysis
epidermal growth factor receptor mutation
Epidermal growth factors
ethnicity
European Continental Ancestry Group - genetics
Exons
Female
Gene mutation
Genetic aspects
Genetic Testing
Humans
Lung Neoplasms - drug therapy
Lung Neoplasms - epidemiology
Lung Neoplasms - genetics
Male
Middle Aged
Mutation
Non-small cell lung cancer
Patient Selection
Prevalence
Pyrazoles - therapeutic use
Pyrimidines - therapeutic use
Real-Time Polymerase Chain Reaction
Receptor, Epidermal Growth Factor - genetics
Retrospective Studies
Small cell lung cancer
Smoking
Tıp
Turkey - epidemiology
Tyrosine
Young Adult
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Description
Summary:mutation analysis in non-small cell lung cancer is important for selecting patients who will receive treatment with tyrosine kinase inhibitors. In this study, we aimed to investigate the prevalence of epidermal growth factor receptor mutations and mutation patterns in the Turkish population. We retrospectively reviewed molecular pathology reports of 959 cases with lung cancer analysed for receptor mutations. We analysed all four receptor exon mutations using a real-time polymerase chain reaction platform. In this study, the mutation rate in the Turkish population was 16.7% (160 of 959). The mutation frequency was significantly higher in women (37.1%, n=96) than in men (9.1%, n=64) (p
ISSN:2146-3123
2146-3131
DOI:10.4274/balkanmedj.2017.0297