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Prevalence of Epidermal Growth Factor Receptor Mutations in Patients with Non-Small Cell Lung Cancer in Turkish Population
mutation analysis in non-small cell lung cancer is important for selecting patients who will receive treatment with tyrosine kinase inhibitors. In this study, we aimed to investigate the prevalence of epidermal growth factor receptor mutations and mutation patterns in the Turkish population. We retr...
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| Published in: | Balkan medical journal 2017-12, Vol.34 (6), p.567-571 |
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| container_end_page | 571 |
| container_issue | 6 |
| container_start_page | 567 |
| container_title | Balkan medical journal |
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| creator | Tezel, Gaye Guler Sener, Ebru Aydin, Cisel Onder, Sevgen |
| description | mutation analysis in non-small cell lung cancer is important for selecting patients who will receive treatment with tyrosine kinase inhibitors. In this study, we aimed to investigate the prevalence of epidermal growth factor receptor mutations and mutation patterns in the Turkish population.
We retrospectively reviewed molecular pathology reports of 959 cases with lung cancer analysed for
receptor mutations. We analysed all four
receptor exon mutations using a real-time polymerase chain reaction platform.
In this study, the
mutation rate in the Turkish population was 16.7% (160 of 959). The
mutation frequency was significantly higher in women (37.1%, n=96) than in men (9.1%, n=64) (p |
| doi_str_mv | 10.4274/balkanmedj.2017.0297 |
| format | article |
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We retrospectively reviewed molecular pathology reports of 959 cases with lung cancer analysed for
receptor mutations. We analysed all four
receptor exon mutations using a real-time polymerase chain reaction platform.
In this study, the
mutation rate in the Turkish population was 16.7% (160 of 959). The
mutation frequency was significantly higher in women (37.1%, n=96) than in men (9.1%, n=64) (p<0.001). In addition, the
mutation rate was higher in the adenocarcinoma histologic type (p<0.001). Patients with mutations were older than those without mutations (p=0.003). The most frequent mutations were exon 19 deletions (48.8%, 78/160) and exon 21 L858R point mutations (38.1.1%, 61/160). We also detected compound mutation patterns in three cases (1.9%).
The prevalence of
receptor mutations in the Turkish population was slightly higher than that in the Caucasian population and lower than that in the East Asian population. The results of this study may provide guidance in personalized therapy of non-small cell lung cancer in the Turkish population.</description><identifier>ISSN: 2146-3123</identifier><identifier>EISSN: 2146-3131</identifier><identifier>DOI: 10.4274/balkanmedj.2017.0297</identifier><identifier>PMID: 28832323</identifier><language>eng</language><publisher>Turkey: Galenos Yayinevi Tic. Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analysis ; Antineoplastic Agents - therapeutic use ; Brief Report ; Carcinoma, Non-Small-Cell Lung - drug therapy ; Carcinoma, Non-Small-Cell Lung - epidemiology ; Carcinoma, Non-Small-Cell Lung - genetics ; Care and treatment ; DNA Mutational Analysis ; epidermal growth factor receptor mutation ; Epidermal growth factors ; ethnicity ; European Continental Ancestry Group - genetics ; Exons ; Female ; Gene mutation ; Genetic aspects ; Genetic Testing ; Humans ; Lung Neoplasms - drug therapy ; Lung Neoplasms - epidemiology ; Lung Neoplasms - genetics ; Male ; Middle Aged ; Mutation ; Non-small cell lung cancer ; Patient Selection ; Prevalence ; Pyrazoles - therapeutic use ; Pyrimidines - therapeutic use ; Real-Time Polymerase Chain Reaction ; Receptor, Epidermal Growth Factor - genetics ; Retrospective Studies ; Small cell lung cancer ; Smoking ; Tıp ; Turkey - epidemiology ; Tyrosine ; Young Adult</subject><ispartof>Balkan medical journal, 2017-12, Vol.34 (6), p.567-571</ispartof><rights>COPYRIGHT 2017 Galenos Yayinevi Tic. Ltd.</rights><rights>Copyright 2017, Trakya University Faculty of Medicine 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-943d39156547895bde7108dfcf9e1f0dbfc650f5615dd77635e1c73d014f5ac93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785663/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785663/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28832323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Koçak,Zafer</contributor><creatorcontrib>Tezel, Gaye Guler</creatorcontrib><creatorcontrib>Sener, Ebru</creatorcontrib><creatorcontrib>Aydin, Cisel</creatorcontrib><creatorcontrib>Onder, Sevgen</creatorcontrib><title>Prevalence of Epidermal Growth Factor Receptor Mutations in Patients with Non-Small Cell Lung Cancer in Turkish Population</title><title>Balkan medical journal</title><addtitle>Balkan Med J</addtitle><description>mutation analysis in non-small cell lung cancer is important for selecting patients who will receive treatment with tyrosine kinase inhibitors. In this study, we aimed to investigate the prevalence of epidermal growth factor receptor mutations and mutation patterns in the Turkish population.
We retrospectively reviewed molecular pathology reports of 959 cases with lung cancer analysed for
receptor mutations. We analysed all four
receptor exon mutations using a real-time polymerase chain reaction platform.
In this study, the
mutation rate in the Turkish population was 16.7% (160 of 959). The
mutation frequency was significantly higher in women (37.1%, n=96) than in men (9.1%, n=64) (p<0.001). In addition, the
mutation rate was higher in the adenocarcinoma histologic type (p<0.001). Patients with mutations were older than those without mutations (p=0.003). The most frequent mutations were exon 19 deletions (48.8%, 78/160) and exon 21 L858R point mutations (38.1.1%, 61/160). We also detected compound mutation patterns in three cases (1.9%).
The prevalence of
receptor mutations in the Turkish population was slightly higher than that in the Caucasian population and lower than that in the East Asian population. The results of this study may provide guidance in personalized therapy of non-small cell lung cancer in the Turkish population.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Brief Report</subject><subject>Carcinoma, Non-Small-Cell Lung - drug therapy</subject><subject>Carcinoma, Non-Small-Cell Lung - epidemiology</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Care and treatment</subject><subject>DNA Mutational Analysis</subject><subject>epidermal growth factor receptor mutation</subject><subject>Epidermal growth factors</subject><subject>ethnicity</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Exons</subject><subject>Female</subject><subject>Gene mutation</subject><subject>Genetic aspects</subject><subject>Genetic Testing</subject><subject>Humans</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Non-small cell lung cancer</subject><subject>Patient Selection</subject><subject>Prevalence</subject><subject>Pyrazoles - therapeutic use</subject><subject>Pyrimidines - therapeutic use</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Receptor, Epidermal Growth Factor - genetics</subject><subject>Retrospective Studies</subject><subject>Small cell lung cancer</subject><subject>Smoking</subject><subject>Tıp</subject><subject>Turkey - epidemiology</subject><subject>Tyrosine</subject><subject>Young Adult</subject><issn>2146-3123</issn><issn>2146-3131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptUl1v0zAUjRCITWP_ACFLPMBLix3HdvKCVJVuVCpQwXi2HH-07lK7OMkm-PXcLKNQiVwpvnLOOc49Pln2kuBpkYviXa2aWxX21uymOSZiivNKPMnOc1LwCSWUPD32OT3LLtt2h-HhmBa0ep6d5WVJc6jz7Nc62TvV2KAtig4tDt7YtFcNuk7xvtuiK6W7mNBXq-1haD71nep8DC3yAa2htaFr0b0H6OcYJt-A2qC5hdeqDxs0VyCcBuxNn259u0XreOibB4kX2TOnmtZePq4X2ferxc3842T15Xo5n60mmgnaTaqCGloRxlkhyorVxgqCS-O0qyxx2NROc4Yd44QZIwSnzBItqMGkcEzpil5ky1HXRLWTh-T3Kv2UUXn5sBHTRqrUed1YWRNbFxXhmoPJXPGS1USQQnOt81pwBVrvR61DX4P7GqZPqjkRPf0S_FZu4p1komScUxB4-yiQ4o_etp3c-1aDXyrY2LeSVDQnHP6BAfTNCIUrUU0MjQ9W7mKfArgllx8Ws5XkuGLDhK9H5AZuUvrgIpytB2E5Y4wLkTNBADX9DwrK2L3XMVjnYf-EUIwEnWLbJuuOcxIshxjKvzGUQwzlEEOgvfrXoyPpT-job-gd2vA</recordid><startdate>20171201</startdate><enddate>20171201</enddate><creator>Tezel, Gaye Guler</creator><creator>Sener, Ebru</creator><creator>Aydin, Cisel</creator><creator>Onder, Sevgen</creator><general>Galenos Yayinevi Tic. Ltd</general><general>Trakya Üniversitesi</general><general>Galenos Publishing</general><general>Galenos Publishing House</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IEBAR</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20171201</creationdate><title>Prevalence of Epidermal Growth Factor Receptor Mutations in Patients with Non-Small Cell Lung Cancer in Turkish Population</title><author>Tezel, Gaye Guler ; Sener, Ebru ; Aydin, Cisel ; Onder, Sevgen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-943d39156547895bde7108dfcf9e1f0dbfc650f5615dd77635e1c73d014f5ac93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Brief Report</topic><topic>Carcinoma, Non-Small-Cell Lung - drug therapy</topic><topic>Carcinoma, Non-Small-Cell Lung - epidemiology</topic><topic>Carcinoma, Non-Small-Cell Lung - genetics</topic><topic>Care and treatment</topic><topic>DNA Mutational Analysis</topic><topic>epidermal growth factor receptor mutation</topic><topic>Epidermal growth factors</topic><topic>ethnicity</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Exons</topic><topic>Female</topic><topic>Gene mutation</topic><topic>Genetic aspects</topic><topic>Genetic Testing</topic><topic>Humans</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Non-small cell lung cancer</topic><topic>Patient Selection</topic><topic>Prevalence</topic><topic>Pyrazoles - therapeutic use</topic><topic>Pyrimidines - therapeutic use</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Receptor, Epidermal Growth Factor - genetics</topic><topic>Retrospective Studies</topic><topic>Small cell lung cancer</topic><topic>Smoking</topic><topic>Tıp</topic><topic>Turkey - epidemiology</topic><topic>Tyrosine</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tezel, Gaye Guler</creatorcontrib><creatorcontrib>Sener, Ebru</creatorcontrib><creatorcontrib>Aydin, Cisel</creatorcontrib><creatorcontrib>Onder, Sevgen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Idealonline online kütüphane - Journals</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Balkan medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tezel, Gaye Guler</au><au>Sener, Ebru</au><au>Aydin, Cisel</au><au>Onder, Sevgen</au><au>Koçak,Zafer</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence of Epidermal Growth Factor Receptor Mutations in Patients with Non-Small Cell Lung Cancer in Turkish Population</atitle><jtitle>Balkan medical journal</jtitle><addtitle>Balkan Med J</addtitle><date>2017-12-01</date><risdate>2017</risdate><volume>34</volume><issue>6</issue><spage>567</spage><epage>571</epage><pages>567-571</pages><issn>2146-3123</issn><eissn>2146-3131</eissn><abstract>mutation analysis in non-small cell lung cancer is important for selecting patients who will receive treatment with tyrosine kinase inhibitors. In this study, we aimed to investigate the prevalence of epidermal growth factor receptor mutations and mutation patterns in the Turkish population.
We retrospectively reviewed molecular pathology reports of 959 cases with lung cancer analysed for
receptor mutations. We analysed all four
receptor exon mutations using a real-time polymerase chain reaction platform.
In this study, the
mutation rate in the Turkish population was 16.7% (160 of 959). The
mutation frequency was significantly higher in women (37.1%, n=96) than in men (9.1%, n=64) (p<0.001). In addition, the
mutation rate was higher in the adenocarcinoma histologic type (p<0.001). Patients with mutations were older than those without mutations (p=0.003). The most frequent mutations were exon 19 deletions (48.8%, 78/160) and exon 21 L858R point mutations (38.1.1%, 61/160). We also detected compound mutation patterns in three cases (1.9%).
The prevalence of
receptor mutations in the Turkish population was slightly higher than that in the Caucasian population and lower than that in the East Asian population. The results of this study may provide guidance in personalized therapy of non-small cell lung cancer in the Turkish population.</abstract><cop>Turkey</cop><pub>Galenos Yayinevi Tic. Ltd</pub><pmid>28832323</pmid><doi>10.4274/balkanmedj.2017.0297</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Balkan medical journal, 2017-12, Vol.34 (6), p.567-571 |
| issn | 2146-3123 2146-3131 |
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| source | Open Access: PubMed Central |
| subjects | Adult Aged Aged, 80 and over Analysis Antineoplastic Agents - therapeutic use Brief Report Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - epidemiology Carcinoma, Non-Small-Cell Lung - genetics Care and treatment DNA Mutational Analysis epidermal growth factor receptor mutation Epidermal growth factors ethnicity European Continental Ancestry Group - genetics Exons Female Gene mutation Genetic aspects Genetic Testing Humans Lung Neoplasms - drug therapy Lung Neoplasms - epidemiology Lung Neoplasms - genetics Male Middle Aged Mutation Non-small cell lung cancer Patient Selection Prevalence Pyrazoles - therapeutic use Pyrimidines - therapeutic use Real-Time Polymerase Chain Reaction Receptor, Epidermal Growth Factor - genetics Retrospective Studies Small cell lung cancer Smoking Tıp Turkey - epidemiology Tyrosine Young Adult |
| title | Prevalence of Epidermal Growth Factor Receptor Mutations in Patients with Non-Small Cell Lung Cancer in Turkish Population |
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