Dietary Tomato Pectin Attenuates Hepatic Insulin Resistance and Inflammation in High-Fat-Diet Mice by Regulating the PI3K/AKT Pathway

Chronic metabolic disease is a serious global health issue, which is accompanied by impaired insulin resistance. Tomato pectin (TP) is a naturally soluble complex hetero-polysaccharide with various biological functions. However, the impact of TP on hepatic insulin resistance in a high-fat diet (HFD)...

Full description

Saved in:
Bibliographic Details
Published in:Foods 2024-01, Vol.13 (3), p.444
Main Authors: Sun, Jing, Wu, Kongyan, Wang, Pan, Wang, Yubin, Wang, Dan, Zhao, Wenting, Zhao, Yuanyuan, Zhang, Chunhong, Zhao, Xiaoyan
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Blood levels
Blood sugar
Diet
Ethylenediaminetetraacetic acid
Global health
Glucose
Glucose tolerance
Health aspects
High fat diet
Homeostasis
Inflammation
Insulin
Insulin resistance
Kinases
Laboratory animals
Lipids
Liver
Liver diseases
Metabolic disorders
Obesity
Oils & fats
Oxidation resistance
Oxidative stress
Pectin
Pharmacology
PI3K/AKT pathway
Polysaccharides
Proteins
Public health
tomato pectin
Tomatoes
Tumor necrosis factor-TNF
World health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chronic metabolic disease is a serious global health issue, which is accompanied by impaired insulin resistance. Tomato pectin (TP) is a naturally soluble complex hetero-polysaccharide with various biological functions. However, the impact of TP on hepatic insulin resistance in a high-fat diet (HFD) and its potential mechanism remains largely unknown. The results revealed that TP treatment significantly decreased the liver weight, hepatic fat accumulation and hepatic injury in HFD-fed mice. TP also improved fasting blood glucose levels and glucose tolerance in HFD-fed mice. The underlying mechanisms involved in the inflammation, oxidative stress and insulin signaling in the liver were also investigated by RT-qPCR and western blot, which indicated that TP ameliorated hepatic insulin resistance by regulating the PI3K/AKT/GSK-3β pathway, increasing the expression of GLUT4, decreasing the expression of PECK and G6P as well as restoring antioxidant activities and suppressing the inflammation statues in HFD-fed mice. Our data showed that dietary TP has profound effects on hepatic insulin resistance, inflammation and oxidative stress, demonstrating that TP might be a promising therapeutic agent against insulin resistance and related chronic metabolic disease.
ISSN:2304-8158
2304-8158
DOI:10.3390/foods13030444