Hyper-Aerotolerant Campylobacter coli from Duck Sources and Its Potential Threat to Public Health: Virulence, Antimicrobial Resistance, and Genetic Relatedness

, a common foodborne human pathogen, is considered sensitive to oxygen. Recently, aerotolerant (AT) with the ability to survive under aerobic stress has been reported. Here, we investigated the prevalence of hyper-aerotolerant (HAT) from duck sources (118 carcasses and meat) and its characteristics...

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Bibliographic Details
Published in:Microorganisms (Basel) 2019-11, Vol.7 (11), p.579
Main Authors: Guk, Jae-Ho, Kim, Junhyung, Song, Hyokeun, Kim, Jinshil, An, Jae-Uk, Kim, Jonghyun, Ryu, Sangryeol, Jeon, Byeonghwa, Cho, Seongbeom
Format: Article
Language:English
Subjects:
Aerotolerance
Antimicrobial agents
Antimicrobial resistance
Aquatic birds
Campylobacter
Campylobacter coli
Ciprofloxacin
Drug resistance
duck sources
Ducks
FlaA protein
Food chains
genetic relatedness
Guillain-Barre syndrome
high-level antimicrobial resistance
hyper-aerotolerance
Infections
Meat
Minimum inhibitory concentration
mlst
Motility
Poultry
Public health
Quinolones
Software
Virulence
virulence potential
Waterfowl
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Summary:, a common foodborne human pathogen, is considered sensitive to oxygen. Recently, aerotolerant (AT) with the ability to survive under aerobic stress has been reported. Here, we investigated the prevalence of hyper-aerotolerant (HAT) from duck sources (118 carcasses and meat) and its characteristics to assess potential impacts on public health. Half of 56 isolates were HAT and most harbored various virulence genes including , , , , and . Moreover, 98.2% of isolates showed resistance to quinolones, including ciprofloxacin (CIP), and nine (16.1%) showed high-level resistance to ciprofloxacin (Minimum Inhibitory Concentration, MIC ≥ 32 μg/mL) and most of these were HAT. Based on genetic relatedness between from duck sources and those from human sources (PubMLST and NCBI), HAT isolates sharing the same MLST sequence types were significantly more prevalent than those not sharing the same sequence types as those from human sources. Therefore, HAT is prevalent in duck sources, and is most likely transmitted to humans through the food chain given its aerotolerance. This being so, it might pose a threat to public health given its virulence and antimicrobial resistance (AMR). This study will assist in improving control strategies to reduce farm-to-table HAT transmission to humans.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms7110579