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Plant-expressed Zika virus envelope protein elicited protective immunity against the Zika virus in immunocompetent mice
Zika virus infection causes multiple clinical issues, including Guillain–Barré syndrome and neonatal malformation. Vaccination is considered as the only strategy for the prevention of ZIKV-induced clinical issues. This study developed a plant-based recombinant vaccine that transiently expressed the...
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| Published in: | Scientific reports 2023-12, Vol.13 (1), p.22955-22955, Article 22955 |
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| creator | Shin, Minna Kang, Hyangju Shin, Kyeong ryeol Lee, Rangyeon Kim, Kiju Min, Kyungmin Cho, Kyou-Nam Sohn, Eun-Ju Kim, Kwang Sung Kim, Seok-Hyun Cho, Yang Je Park, Jeongho Hahn, Tae-Wook |
| description | Zika virus infection causes multiple clinical issues, including Guillain–Barré syndrome and neonatal malformation. Vaccination is considered as the only strategy for the prevention of ZIKV-induced clinical issues. This study developed a plant-based recombinant vaccine that transiently expressed the ZIKV envelope protein (ZikaEnv:aghFc) in
Nicotiana benthamiana
and evaluated the protective immunity afforded by it in immunocompetent mice. ZikaEnv:aghFc induced both humoral and cellular immunity at a low dose (1–5 μg). This immune-inducing potential was enhanced further when adjuvanted CIA09A. In addition, antigen-specific antibodies and neutralizing antibodies were vertically transferred from immunized females to their progeny and afforded both protective immunity to ZIKV and cross-protection to Dengue virus infection. These results suggest that our plant-based ZIKV vaccine provides a safe and efficient protective strategy with a competitive edge. |
| doi_str_mv | 10.1038/s41598-023-47428-7 |
| format | article |
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Nicotiana benthamiana
and evaluated the protective immunity afforded by it in immunocompetent mice. ZikaEnv:aghFc induced both humoral and cellular immunity at a low dose (1–5 μg). This immune-inducing potential was enhanced further when adjuvanted CIA09A. In addition, antigen-specific antibodies and neutralizing antibodies were vertically transferred from immunized females to their progeny and afforded both protective immunity to ZIKV and cross-protection to Dengue virus infection. These results suggest that our plant-based ZIKV vaccine provides a safe and efficient protective strategy with a competitive edge.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-023-47428-7</identifier><identifier>PMID: 38151523</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699 ; 692/699/255 ; 692/699/255/2514 ; Aluminum ; Animals ; Antibodies ; Antibodies, Neutralizing ; Antibodies, Viral ; Antigen presentation ; Cell-mediated immunity ; Cross-protection ; Cytokines ; Dengue fever ; Env protein ; Female ; Genetic crosses ; Guillain-Barre syndrome ; Humanities and Social Sciences ; Humoral immunity ; Immunization ; Immunocompetence ; Infections ; Mice ; multidisciplinary ; Neonates ; Proteins ; Science ; Science (multidisciplinary) ; Vaccines ; Vector-borne diseases ; Veterinary medicine ; Viral envelope proteins ; Viral Envelope Proteins - genetics ; Viral Vaccines ; Viruses ; West Nile virus ; Zika Virus ; Zika Virus Infection</subject><ispartof>Scientific reports, 2023-12, Vol.13 (1), p.22955-22955, Article 22955</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-1aacbd3a24b271e0e41f9b5c509281d0de05bd657f9a2339d87f7cdd0dab17eb3</citedby><cites>FETCH-LOGICAL-c541t-1aacbd3a24b271e0e41f9b5c509281d0de05bd657f9a2339d87f7cdd0dab17eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2906651240/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2906651240?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38151523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shin, Minna</creatorcontrib><creatorcontrib>Kang, Hyangju</creatorcontrib><creatorcontrib>Shin, Kyeong ryeol</creatorcontrib><creatorcontrib>Lee, Rangyeon</creatorcontrib><creatorcontrib>Kim, Kiju</creatorcontrib><creatorcontrib>Min, Kyungmin</creatorcontrib><creatorcontrib>Cho, Kyou-Nam</creatorcontrib><creatorcontrib>Sohn, Eun-Ju</creatorcontrib><creatorcontrib>Kim, Kwang Sung</creatorcontrib><creatorcontrib>Kim, Seok-Hyun</creatorcontrib><creatorcontrib>Cho, Yang Je</creatorcontrib><creatorcontrib>Park, Jeongho</creatorcontrib><creatorcontrib>Hahn, Tae-Wook</creatorcontrib><title>Plant-expressed Zika virus envelope protein elicited protective immunity against the Zika virus in immunocompetent mice</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Zika virus infection causes multiple clinical issues, including Guillain–Barré syndrome and neonatal malformation. Vaccination is considered as the only strategy for the prevention of ZIKV-induced clinical issues. This study developed a plant-based recombinant vaccine that transiently expressed the ZIKV envelope protein (ZikaEnv:aghFc) in
Nicotiana benthamiana
and evaluated the protective immunity afforded by it in immunocompetent mice. ZikaEnv:aghFc induced both humoral and cellular immunity at a low dose (1–5 μg). This immune-inducing potential was enhanced further when adjuvanted CIA09A. In addition, antigen-specific antibodies and neutralizing antibodies were vertically transferred from immunized females to their progeny and afforded both protective immunity to ZIKV and cross-protection to Dengue virus infection. These results suggest that our plant-based ZIKV vaccine provides a safe and efficient protective strategy with a competitive edge.</description><subject>692/699</subject><subject>692/699/255</subject><subject>692/699/255/2514</subject><subject>Aluminum</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Neutralizing</subject><subject>Antibodies, Viral</subject><subject>Antigen presentation</subject><subject>Cell-mediated immunity</subject><subject>Cross-protection</subject><subject>Cytokines</subject><subject>Dengue fever</subject><subject>Env protein</subject><subject>Female</subject><subject>Genetic crosses</subject><subject>Guillain-Barre syndrome</subject><subject>Humanities and Social Sciences</subject><subject>Humoral immunity</subject><subject>Immunization</subject><subject>Immunocompetence</subject><subject>Infections</subject><subject>Mice</subject><subject>multidisciplinary</subject><subject>Neonates</subject><subject>Proteins</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Vaccines</subject><subject>Vector-borne diseases</subject><subject>Veterinary medicine</subject><subject>Viral envelope proteins</subject><subject>Viral Envelope Proteins - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shin, Minna</au><au>Kang, Hyangju</au><au>Shin, Kyeong ryeol</au><au>Lee, Rangyeon</au><au>Kim, Kiju</au><au>Min, Kyungmin</au><au>Cho, Kyou-Nam</au><au>Sohn, Eun-Ju</au><au>Kim, Kwang Sung</au><au>Kim, Seok-Hyun</au><au>Cho, Yang Je</au><au>Park, Jeongho</au><au>Hahn, Tae-Wook</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plant-expressed Zika virus envelope protein elicited protective immunity against the Zika virus in immunocompetent mice</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2023-12-27</date><risdate>2023</risdate><volume>13</volume><issue>1</issue><spage>22955</spage><epage>22955</epage><pages>22955-22955</pages><artnum>22955</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Zika virus infection causes multiple clinical issues, including Guillain–Barré syndrome and neonatal malformation. Vaccination is considered as the only strategy for the prevention of ZIKV-induced clinical issues. This study developed a plant-based recombinant vaccine that transiently expressed the ZIKV envelope protein (ZikaEnv:aghFc) in
Nicotiana benthamiana
and evaluated the protective immunity afforded by it in immunocompetent mice. ZikaEnv:aghFc induced both humoral and cellular immunity at a low dose (1–5 μg). This immune-inducing potential was enhanced further when adjuvanted CIA09A. In addition, antigen-specific antibodies and neutralizing antibodies were vertically transferred from immunized females to their progeny and afforded both protective immunity to ZIKV and cross-protection to Dengue virus infection. These results suggest that our plant-based ZIKV vaccine provides a safe and efficient protective strategy with a competitive edge.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>38151523</pmid><doi>10.1038/s41598-023-47428-7</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/699 692/699/255 692/699/255/2514 Aluminum Animals Antibodies Antibodies, Neutralizing Antibodies, Viral Antigen presentation Cell-mediated immunity Cross-protection Cytokines Dengue fever Env protein Female Genetic crosses Guillain-Barre syndrome Humanities and Social Sciences Humoral immunity Immunization Immunocompetence Infections Mice multidisciplinary Neonates Proteins Science Science (multidisciplinary) Vaccines Vector-borne diseases Veterinary medicine Viral envelope proteins Viral Envelope Proteins - genetics Viral Vaccines Viruses West Nile virus Zika Virus Zika Virus Infection |
| title | Plant-expressed Zika virus envelope protein elicited protective immunity against the Zika virus in immunocompetent mice |
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