Phytocomplex Influences Antimicrobial and Health Properties of Concentrated Glycerine Macerates

The purpose of this study was to correlate the chemical composition of four commercial concentrated glycerine macerates (C-GMs), produced through the same extraction method, with their in vitro antimicrobial, antioxidant, and immunomodulatory properties, in order to evaluate their potential for heal...

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Bibliographic Details
Published in:Antibiotics (Basel) 2020-12, Vol.9 (12), p.858
Main Authors: Di Vito, Maura, Gentile, Margherita, Mattarelli, Paola, Barbanti, Lorenzo, Micheli, Laura, Mazzuca, Claudia, Garzoli, Stefania, Titubante, Mattia, Vitali, Alberto, Cacaci, Margherita, Sanguinetti, Maurizio, Bugli, Francesca
Format: Article
Language:English
Subjects:
Alcohol
Alnus glutinosa
Antiinfectives and antibacterials
Antimicrobial agents
Antioxidants
Biological activity
Carpinus betulus
Chemical composition
Correlation analysis
Cultivation
Cytokines
Cytotoxicity
Data integration
Dilution
Enzyme-linked immunosorbent assay
Evaluation
Fatty acids
Ficus carica
Glycerol
Herbal medicine
High-performance liquid chromatography
IM-SPME/GC-MS system
Immunomodulation
In vitro methods and tests
Liquid chromatography
Microbial activity
Microorganisms
Oxidants
Oxidizing agents
Probiotics
Respiratory tract diseases
Ribes nigrum
Solid phase methods
Toxicity
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Summary:The purpose of this study was to correlate the chemical composition of four commercial concentrated glycerine macerates (C-GMs), produced through the same extraction method, with their in vitro antimicrobial, antioxidant, and immunomodulatory properties, in order to evaluate their potential for healing upper airway diseases. C-GMs of (CB), (FC), (AG) and (RN) were studied. The quality was evaluated using HPLC and IM-SPME/GC-MS systems; anti-oxidant and anti-microbial activities were assessed by the respective DPPH test, and micro-broth dilution test performed against 10 strains of and 10 probiotic strains. ELISA and MTT tests were used to assess the immunomodulatory activity and the cytotoxicity of C-GMs, respectively. A significant correlation was found between the number of active compounds and the in vitro C-GMs effectiveness. Furthermore, the C-GMs of AG showed the best anti-microbial activity on pathological strains and, together with CB, the best anti-oxidant activity. The ELISA test exhibited a good immunomodulatory activity of RN. In vitro data support the integrated use of C-GMs of CB, AG, and RN in presence of airway diseases, and highlight the importance of standard procedures in cultivation, harvest and post-harvest treatments, as a premise for C-GMs with consistent characteristics.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics9120858