Prognostic value of inflammation-based indices in patients with resected hepatocellular carcinoma

As is well recognized that inflammation plays a crucial role in the genesis and progression of various cancer. Here we investigate the prognostic value of a novel index: the combination of neutrophil to lymphocyte ratio and platelet distribution width (coNLR-PDW) in post-operation patients with rese...

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Bibliographic Details
Published in:BMC cancer 2021-04, Vol.21 (1), p.469-9, Article 469
Main Authors: Kong, Weihao, Yang, Mingwei, Zhang, Jianfeng, Cheng, Ya, Dai, Tianxing, Zhang, Jian, Wang, Guoying, Zhang, Jianlin
Format: Article
Language:English
Subjects:
Biological markers
Biomarkers
Blood
Cancer
Cancer therapies
Care and treatment
Diagnosis
Hepatitis
Hepatocellular carcinoma
Hepatoma
Hospitals
Inflammation
Leukocytes (neutrophilic)
Liver cancer
Lung cancer
Lymphocytes
Medical examination
Medical prognosis
Metastasis
Neutrophil-to-lymphocyte ratio
Neutrophils
Oncology, Experimental
Patients
Platelet distribution width
Platelets
Prognosis
Reference values (Medicine)
Regression analysis
Statistical analysis
Surgery
Survival analysis
Tumors
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Summary:As is well recognized that inflammation plays a crucial role in the genesis and progression of various cancer. Here we investigate the prognostic value of a novel index: the combination of neutrophil to lymphocyte ratio and platelet distribution width (coNLR-PDW) in post-operation patients with resectable hepatocellular carcinoma (HCC). The receiver operating characteristic (ROC) curve was utilized to determine the optimal cutoff values of continuous variables, including the neutrophil-lymphocyte ratio (NLR) and platelet distribution width (PDW). Kaplan-Meier method and the Log-rank test were used to compare survival differences across three groups stratified by the coNLR-PDW score. Univariate and multivariate Cox proportional hazard regression analyses were adopted to identify independent factors of HCC patient's prognosis. 1.59 and 13.0 were perceived as the optimal cutoff value for NLR and PDW based on the ROC curve, respectively. Kaplan-Meier method revealed that a higher coNLR-PDW score predicts poorer overall survival (OS) and disease-free survival (DFS) (P 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-021-08153-4