Testicular inflammation in male reproductive system

The control of the immune system, neuroendocrine system, and energy metabolism is essential for the physiological process of male reproduction. The hypothalamic-pituitary-testicular (HPT) axis regulates the generation of gonadal steroid hormones in the testes, which in turn controls spermatogenesis....

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Bibliographic Details
Published in:Exploration of immunology 2024-08, Vol.4 (4), p.446-464
Main Authors: Yadav, Prity, Mali, Pratap Chand
Format: Article
Language:English
Subjects:
cytokines
hpt
immunometabolism
neuroendocrine
spermatogenesis
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Summary:The control of the immune system, neuroendocrine system, and energy metabolism is essential for the physiological process of male reproduction. The hypothalamic-pituitary-testicular (HPT) axis regulates the generation of gonadal steroid hormones in the testes, which in turn controls spermatogenesis. For the growth and maturation of germ cells, the immune cells and cytokines in the testes offer a safe microenvironment. The cellular reactions and metabolic activities in the testes produce energy and biosynthetic precursors that control the growth of germ cells, as well as testicular immunology and inflammation. Both inflammatory and anti-inflammatory responses depend on immune cell metabolism, which is thought to influence testicular spermatogenesis. The significance of immunometabolism in male reproduction will be underlined in this review.
ISSN:2768-6655
2768-6655
DOI:10.37349/ei.2024.00151