Essential Oil Stabilisation by Response Surface Methodology (RSM): Nanoemulsion Formulation, Physicochemical, Microbiological, and Sensory Investigations

This manuscript aimed to optimise the encapsulation of Thymus capitatus essential oil into nanoemulsion. Response Surface Methodology results were best fitted into polynomial models with regression coefficient values of more than 0.95. The optimal nanoemulsion showed nanometer-sized droplets (380 nm...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2022-10, Vol.27 (21), p.7330
Main Authors: BenJemaa, Mariem, Rahali, Fatma Zohra, Falleh, Hanen, Beji-Serairi, Raja, Megdiche-Ksouri, Wided, Hamrouni, Ibtissem, Hammami, Majdi, Nehme, Ralph, Pereira, Renato B., Andrés, Sonia, Bouhallab, Said, Pereira, David M., Ceciliani, Fabrizio, Abdennebi-Najar, Latifa, Ksouri, Riadh
Format: Article
Language:English
Subjects:
Analysis
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
biological activities
Drug resistance
Encapsulation
Enrichment
essential oil
Essential oils
Food
Food and Nutrition
Independent variables
Investigations
Life Sciences
Methods
Microbiology
Milk
nanoemulsion
Nanoemulsions
Oils & fats
Particle size
physical characterisation
Polydispersity
Polynomials
Regression analysis
Regression coefficients
Response surface methodology
RSM experimental design
sensory analysis
Sensory evaluation
Software
Thyme
Variance analysis
Zeta potential
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Summary:This manuscript aimed to optimise the encapsulation of Thymus capitatus essential oil into nanoemulsion. Response Surface Methodology results were best fitted into polynomial models with regression coefficient values of more than 0.95. The optimal nanoemulsion showed nanometer-sized droplets (380 nm), a polydispersity index less than 0.5, and a suitable Zeta potential (−10.3 mV). Stability results showed that nanoemulsions stored at 4 °C were stable with the lowest d3,2, PolyDispersity Index (PDI), and pH (day 11). Significant ameliorations in the capacity to neutralise DPPH radical after the encapsulation of the antimicrobial efficacy of thyme essential oil were recorded. S. typhimurium growth inhibition generated by nanoencapsulated thyme essential oil was 17 times higher than by bulk essential oil. The sensory analysis highlighted that the encapsulation of thyme essential oil improved enriched milk’s sensory appreciation. Indeed, 20% of the total population attributed a score of 4 and 5 on the scale used for milk enriched with nanoemulsion. In comparison, only 11% attributed the same score to milk enriched with bulk essential oil. The novel nanometric delivery system presents significant interest for agroalimentary industries.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27217330