Rutin—Increased Antioxidant Activity and Skin Penetration by Nanocrystal Technology (smartCrystals)

Rutin is a well-known antioxidant from the group of flavonoids. Its use in cosmetic dermal products is, however, limited due to its poor water solubility. In order to increase rutin saturation solubility and improve the diffusion to the skin, rutin nanocrystals were produced by the smartCrystal proc...

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Bibliographic Details
Published in:Cosmetics (Basel) 2016-03, Vol.3 (1), p.9
Main Authors: Pyo, Sung, Meinke, Martina, Keck, Cornelia, Müller, Rainer
Format: Article
Language:English
Subjects:
Antioxidants
bioactivity
Biological activity
Cellulose
Conflicts of interest
Crystals
DPPH assay
Drug delivery systems
ex vivo penetration study
Flavonoids
Free radicals
Glycerol
Homogenization
in vitro antioxidant activity
nanocrystals
Pharmaceuticals
Pharmacy
poor solubility
Powder
radical scavenging
Rutin
Skin
smartCrystals
Solubility
Stratum corneum
tape stripping
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Summary:Rutin is a well-known antioxidant from the group of flavonoids. Its use in cosmetic dermal products is, however, limited due to its poor water solubility. In order to increase rutin saturation solubility and improve the diffusion to the skin, rutin nanocrystals were produced by the smartCrystal process, e.g., bead milling followed by high pressure homogenization. Rutin nanocrystals were further incorporated into hydroxypropyl cellulose (HPC) gel and its long-term stability was assessed. Determination of the antioxidant activity was made by the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay for these formulations: rutin nanocrystals (mean size 300 nm), rutin raw drug powder (mean size 33 μm) and commercial product. Furthermore, the skin penetration profile of rutin was investigated by the tape-stripping method on porcine skin. This study demonstrated that rutin nanocrystal gel had the highest neutralizing activity (90%), followed by a commercial product and rutin raw drug powder. According to the skin study, rutin nanocrystals penetrated to the deeper layers of the stratum corneum, the horny layer of the skin.
ISSN:2079-9284
2079-9284
DOI:10.3390/cosmetics3010009