Glioblastoma Tumor Microenvironment: An Important Modulator for Tumoral Progression and Therapy Resistance

The race to find an effective treatment for glioblastoma (GBM) remains a critical topic, because of its high aggressivity and impact on survival and the quality of life. Currently, due to GBM's high heterogeneity, the conventional treatment success rate and response to therapy are relatively lo...

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Bibliographic Details
Published in:Current issues in molecular biology 2024-09, Vol.46 (9), p.9881-9894
Main Authors: Tataranu, Ligia Gabriela, Turliuc, Serban, Kamel, Amira, Rizea, Radu Eugen, Dricu, Anica, Staicu, Georgiana-Adeline, Baloi, Stefania Carina, Rodriguez, Silvia Mara Baez, Manole, Andrada Ioana Maria
Format: Article
Language:English
Subjects:
extracellular matrix
glioblastoma
molecular diagnostic
Review
tumor microenvironment
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Summary:The race to find an effective treatment for glioblastoma (GBM) remains a critical topic, because of its high aggressivity and impact on survival and the quality of life. Currently, due to GBM's high heterogeneity, the conventional treatment success rate and response to therapy are relatively low, with a median survival rate of less than 20 months. A new point of view can be provided by the comprehension of the tumor microenvironment (TME) in pursuance of the development of new therapeutic strategies to aim for a longer survival rate with an improved quality of life and longer disease-free interval (DFI). The main components of the GBM TME are represented by the extracellular matrix (ECM), glioma cells and glioma stem cells (GSCs), immune cells (microglia, macrophages, neutrophils, lymphocytes), neuronal cells, all of them having dynamic interactions and being able to influence the tumoral growth, progression, and drug resistance thus being a potential therapeutic target. This paper will review the latest research on the GBM TME and the potential therapeutic targets to form an up-to-date strategy.
ISSN:1467-3045
1467-3037
1467-3045
DOI:10.3390/cimb46090588