The Factors and Pathways Regulating the Activation of Mammalian Primordial Follicles in vivo

Mammalian ovaries consist of follicles as basic functional units. Each follicle comprised an innermost oocyte and several surrounding flattened granulosa cells. Unlike males, according to the initial size of the primordial follicle pool and the rate of its activation and depletion, a female’s reprod...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in cell and developmental biology 2020-09, Vol.8, p.575706-575706
Main Authors: Chen, Yao, Yang, Weina, Shi, Xu, Zhang, Chenlu, Song, Ge, Huang, Donghui
Format: Article
Language:English
Subjects:
activation
Cell and Developmental Biology
factors
mechanism
primordial follicle
signaling pathways
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Mammalian ovaries consist of follicles as basic functional units. Each follicle comprised an innermost oocyte and several surrounding flattened granulosa cells. Unlike males, according to the initial size of the primordial follicle pool and the rate of its activation and depletion, a female’s reproductive life has been determined early in life. Primordial follicles, once activated, will get into an irreversible process of development. Most follicles undergo atretic degeneration, and only a few of them could mature and ovulate. Although there are a lot of researches contributing to exploring the activation of primordial follicles, little is known about its underlying mechanisms. Thus, in this review, we collected the latest papers and summarized the signaling pathways as well as some factors involved in the activation of primordial follicles, hoping to lead to a more profound understanding of the cellular and molecular mechanisms of primordial follicle activation.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2020.575706