Blood oxygenation level-dependent MRI for assessment of renal oxygenation

Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) has recently emerged as an important noninvasive technique to assess intrarenal oxygenation under physiologic and pathophysiologic conditions. Although this tool represents a major addition to our armamentarium of methodologies to in...

Full description

Saved in:
Bibliographic Details
Published in:International journal of nephrology and renovascular disease 2014-01, Vol.7 (default), p.421-435
Main Authors: Neugarten, Joel, Golestaneh, Ladan
Format: Article
Language:English
Subjects:
Diagnosis
Hemoglobin
Hydration
Hypertension
Hypoxia
Kidney diseases
Kidneys
Magnetic resonance imaging
Methods
NMR
Nuclear magnetic resonance
Oxygen
Patient monitoring
Physiological transport
Review
Sodium
Veins & arteries
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) has recently emerged as an important noninvasive technique to assess intrarenal oxygenation under physiologic and pathophysiologic conditions. Although this tool represents a major addition to our armamentarium of methodologies to investigate the role of hypoxia in the pathogenesis of acute kidney injury and progressive chronic kidney disease, numerous technical limitations confound interpretation of data derived from this approach. BOLD MRI has been utilized to assess intrarenal oxygenation in numerous experimental models of kidney disease and in human subjects with diabetic and nondiabetic chronic kidney disease, acute kidney injury, renal allograft rejection, contrast-associated nephropathy, and obstructive uropathy. However, confidence in conclusions based on data derived from BOLD MRI measurements will require continuing advances and technical refinements in the use of this technique.
ISSN:1178-7058
1178-7058
DOI:10.2147/IJNRD.S42924