Synthesis and antibacterial activity of novel N-acylsulfonamides

A series of novel N-acylsulfonamide derivatives were synthesized and characterized by 1H NMR, 13C NMR and HRMS. The N-acylsulfonamides were prepared in four steps (carbamoylation, sulfamoylation, deprotection and acylation) starting from chlorosulfonyl isocyanate. These compounds were evaluated in v...

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Bibliographic Details
Published in:Arabian journal of chemistry 2017-02, Vol.10 (S1), p.S1095-S1099
Main Authors: Berredjem, Malika, Bouchareb, Fouzia, Kaki, Samira Ait, Dekhil, Maazouz, Aouf, Nour-Eddine
Format: Article
Language:English
Subjects:
Acylation
Acylsulfonamide
Antibacterial activity
Chlorosulfonyl isocyanate
Sulfonamide
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Summary:A series of novel N-acylsulfonamide derivatives were synthesized and characterized by 1H NMR, 13C NMR and HRMS. The N-acylsulfonamides were prepared in four steps (carbamoylation, sulfamoylation, deprotection and acylation) starting from chlorosulfonyl isocyanate. These compounds were evaluated in vitro as antimicrobial agents against representative strains of Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli, Acinetobacter, Klebsiella pneumonia and Pseudomonas aeruginosa).
ISSN:1878-5352
1878-5379
DOI:10.1016/j.arabjc.2013.01.016