Synthesis of N -(4-propargylaminobenzoyl)-L-glutamates

To facilitate the rather labour consuming synthesis of antifolate γ-oligo-L-glutamates including those with the propargyl group at position N , two synthons possessing this group, α-t-butyl γ-methyl N-(4-propargylaminobenzoyl)- L-glutamate (1) and a-t-butyl N-(4-propargylaminobenzoyl)-L-glutamate (2...

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Bibliographic Details
Published in:Pteridines 1994-11, Vol.5 (4), p.129-132
Main Authors: Kempny, Michal, Rzeszotarska, Barbara, Pawelczak, Krzysztof
Format: Article
Language:English
Subjects:
HPLC
N-(4-propargylaminobenzoyl)-L-glutamates
N10-propargyl antifolates. 'H NMR spectra
Short column chromatography
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Summary:To facilitate the rather labour consuming synthesis of antifolate γ-oligo-L-glutamates including those with the propargyl group at position N , two synthons possessing this group, α-t-butyl γ-methyl N-(4-propargylaminobenzoyl)- L-glutamate (1) and a-t-butyl N-(4-propargylaminobenzoyl)-L-glutamate (2) have been elaborated (Scheme 2) and characterized by melting points, elemental analysis, NMR, TLC and HPLC. They are of purity >98.5% by the last method.
ISSN:0933-4807
2195-4720
DOI:10.1515/pteridines.1994.5.4.129