Tonsil histopathology in HIV-infected versus HIV-uninfected adults

Background: The relationship between HIV and tonsil malignancy has not been fully investigated and established. Both of these diseases prominently feature in the Otorhinolaryngology clinics.Objective: There is minimal data available on the histopathology of tonsillectomy specimens in the HIV-infecte...

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Bibliographic Details
Published in:Southern African journal of HIV medicine 2019, Vol.20 (1), p.1-5
Main Authors: Hari, Kapila, Motakef, Shahpar, Essa, Ridwaan, Maharaj, Shivesh
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adults
Age
AIDS
Biology
Cancer
CD4 antigen
Health Care Sciences & Services
Health Policy & Services
Histochemistry
Histology
Histopathology
HIV
HIV infections
HIV patients
HIV-infected patients
HIV-uninfected patients
Human immunodeficiency virus
Human papillomavirus
Hyperplasia
Immunology
Infections
Laboratories
Lymphoma
Malignancy
Medical research
Original Research
Otolaryngology
Patients
Risk factors
Studies
Systematic review
Throat surgery
Tonsil
Tonsillectomy
Tuberculosis
Viral infections
Viruses
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Summary:Background: The relationship between HIV and tonsil malignancy has not been fully investigated and established. Both of these diseases prominently feature in the Otorhinolaryngology clinics.Objective: There is minimal data available on the histopathology of tonsillectomy specimens in the HIV-infected population. This retrospective review compared tonsil histopathology between HIV-infected and HIV-uninfected patients.Methods: Of the 319 adult patients undergoing tonsillectomy (01 July 2005 to 30 June 2015), HIV results were available for 160. The histological findings were compared in the HIVinfected and HIV-uninfected subgroups. The effects of age, HIV status and CD4 count on the risk of malignancy were determined.Results: There were 86 patients who were HIV-infected and 74 were uninfected. Reactive lymphoid hyperplasia was the most common diagnosis in both groups (77%). Malignancies were diagnosed in eight HIV-infected and six HIV-uninfected patients, an insignificant difference.Conclusion: The majority of patients undergoing tonsillectomy had benign conditions. HIV status does not appear to be a specific risk factor for tonsil malignancies, but advanced age may be.
ISSN:1608-9693
2078-6751
2078-6751
DOI:10.4102/sajhivmed.v20i1.936