Targeting Neutrophils in Sepsis: From Mechanism to Translation

Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Although our understanding in the pathophysiological features of sepsis has increased significantly during the past decades, there is still lack of specific treatment for sepsis. Neutrophils are important reg...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in pharmacology 2021-04, Vol.12, p.644270-644270
Main Authors: Shen, Xiaofei, Cao, Ke, Zhao, Yang, Du, Junfeng
Format: Article
Language:English
Subjects:
neutrophil
Pharmacology
sepsis
Signaling pathway
therapeutic target
translational medicine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Although our understanding in the pathophysiological features of sepsis has increased significantly during the past decades, there is still lack of specific treatment for sepsis. Neutrophils are important regulators against invading pathogens, and their role during sepsis has been studied extensively. It has been suggested that the migration, the antimicrobial activity, and the function of neutrophil extracellular traps (NETs) have all been impaired during sepsis, which results in an inappropriate response to primary infection and potentially increase the susceptibility to secondary infection. On the other hand, accumulating evidence has shown that the reversal or restoration of neutrophil function can promote bacterial clearance and improve sepsis outcome, supporting the idea that targeting neutrophils may be a promising strategy for sepsis treatment. In this review, we will give an overview of the role of neutrophils during sepsis and discuss the potential therapeutic strategy targeting neutrophils.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2021.644270