Synthesis and Antimicrobial Activities of Some New Heterocyclic Compounds Based on 6-Chloropyridazine-3(2H)-thione

Three tricyclic ring system, pyridazino[6,1-b]quinazolin-10-ones, benzimidazolo-pyridazine thione, and 1,2,4-benzotriazino-pyridazinethione along with imidazo-[1,2-b]-pyridazinethione, 1,2,4-triazolo[4,3-b]pyridazine-thione derivatives were synthesized starting from 6-chloropyridazin3-(2H)-thione. S...

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Bibliographic Details
Published in:Journal of chemistry 2013-01, Vol.2013 (1)
Main Authors: Abd El-Salam, Nasser M., Mostafa, Mohamed S., Ahmed, Gamal A., Alothman, Othman Y.
Format: Article
Language:English
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Summary:Three tricyclic ring system, pyridazino[6,1-b]quinazolin-10-ones, benzimidazolo-pyridazine thione, and 1,2,4-benzotriazino-pyridazinethione along with imidazo-[1,2-b]-pyridazinethione, 1,2,4-triazolo[4,3-b]pyridazine-thione derivatives were synthesized starting from 6-chloropyridazin3-(2H)-thione. Some disulfide and sulfide derivatives were also prepared. The antimicrobial activity of the synthesized compounds was tested. Some of these compounds possess a highly response against gram-positive and gram-negative bacteria as well as fungi.
ISSN:2090-9063
2090-9071
DOI:10.1155/2013/890617