Sleep-disordered breathing and heart failure: a vicious cycle of cardiovascular risk

Sleep-disordered breathing (SDB) represents an important cardiovascular risk factor that is still often underestimated and not always optimally treated. Such breathing disorders can induce several harmful effects on the heart, also favoring the development of arrhythmias, ischemic heart disease, and...

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Bibliographic Details
Published in:Monaldi archives for chest disease 2023-09
Main Authors: Cacciapuoti, Fulvio, D'Onofrio, Antonio, Tarquinio, Luca Gaetano, Capone, Valentina, Mauro, Ciro, Marfella, Raffaele, Cacciapuoti, Federico
Format: Article
Language:English
Subjects:
heart failure
sleep apnea syndrome
sleep-disordered breathing
sodium-glucose cotransporter type 2 inhibitors
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Summary:Sleep-disordered breathing (SDB) represents an important cardiovascular risk factor that is still often underestimated and not always optimally treated. Such breathing disorders can induce several harmful effects on the heart, also favoring the development of arrhythmias, ischemic heart disease, and left ventricular remodeling. Obstructive sleep apnea syndrome (OSA) is more frequent in heart failure patients than in the general population, promoting the worsening of left ventricular dysfunction. Both sleep apnea and heart failure have common clinical manifestations but also similar neurohormonal characteristics, both contributing to the development and progression of heart failure and resulting in increased mortality. The pathophysiological mechanisms underlying left ventricular dysfunction associated with SDB will be analyzed, and the potential therapeutic effects of gliflozins on OSA in heart failure patients will be discussed.
ISSN:1122-0643
2532-5264
DOI:10.4081/monaldi.2023.2660