Pathogenesis and Transmissibility of North American Highly Pathogenic Avian Influenza A(H5N1) Virus in Ferrets

Highly pathogenic avian influenza A(H5N1) viruses have spread rapidly throughout North American flyways in recent months, affecting wild birds in over 40 states. We evaluated the pathogenicity and transmissibility of a representative virus using a ferret model and examined replication kinetics of th...

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Bibliographic Details
Published in:Emerging infectious diseases 2022-09, Vol.28 (9), p.1913-1915
Main Authors: Pulit-Penaloza, Joanna A, Belser, Jessica A, Brock, Nicole, Thakur, Poulami Basu, Tumpey, Terrence M, Maines, Taronna R
Format: Article
Language:English
Subjects:
Animals
Avian flu
Avian influenza
Birds
cell culture
Development and progression
Disease control
Disease prevention
Disease transmission
ferret
Ferrets
Health aspects
Humans
influenza
Influenza A virus
Influenza A Virus, H5N1 Subtype - genetics
Influenza in Birds - epidemiology
Influenza, Human
Laboratory animals
Medical laboratories
North America - epidemiology
Orthomyxoviridae Infections - veterinary
Pandemics
Pathogenesis
Poultry
Research Letter
Risk assessment
Risk factors
transmission
Viruses
Zoonoses
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Summary:Highly pathogenic avian influenza A(H5N1) viruses have spread rapidly throughout North American flyways in recent months, affecting wild birds in over 40 states. We evaluated the pathogenicity and transmissibility of a representative virus using a ferret model and examined replication kinetics of this virus in human respiratory tract cells.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2809.220879