Oxidative stress in patients with endodontic pathologies

Apical periodontitis (AP) is an inflammatory disease affecting periradicular tissues. It is a widespread condition but its etiopathogenetic mechanisms have not been completely elucidated and the current treatment options are not always successful. To compare oxidative stress (OxS) levels in the sali...

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Bibliographic Details
Published in:Journal of pain research 2017-01, Vol.10, p.2031-2040
Main Authors: Vengerfeldt, Veiko, Mändar, Reet, Saag, Mare, Piir, Anneli, Kullisaar, Tiiu
Format: Article
Language:English
Subjects:
Antioxidants
apical periodontitis
Complications and side effects
Defense mechanisms
dental pulp cavity
Dentists
Endodontics
Ethics
Fatty acids
Genetic aspects
irreversible pulpitis
Lipid peroxidation
Lipids
Original Research
Oxidative stress
Pain
Pathogenesis
Pathology
Periodontitis
Risk factors
saliva
Studies
Teeth
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Summary:Apical periodontitis (AP) is an inflammatory disease affecting periradicular tissues. It is a widespread condition but its etiopathogenetic mechanisms have not been completely elucidated and the current treatment options are not always successful. To compare oxidative stress (OxS) levels in the saliva and the endodontium (root canal [RC] contents) in patients with different endodontic pathologies and in endodontically healthy subjects. The study group of this comparison study included 22 subjects with primary chronic apical periodontitis (pCAP), 26 with posttreatment or secondary chronic apical periodontitis (sCAP), eight with acute periapical abscess, 13 with irreversible pulpitis, and 17 healthy controls. Resting saliva samples were collected before clinical treatment. Pulp samples (remnants of the pulp, tooth tissue, and/or previous root filling material) were collected under strict aseptic conditions using the Hedström file. The samples were frozen to -80°C until analysis. OxS markers (myeloperoxidase [MPO], oxidative stress index [OSI], 8-isoprostanes [8-EPI]) were detected in the saliva and the endodontium. The highest MPO and 8-EPI levels were seen in pCAP and pulpitis, while the highest levels of OSI were seen in pCAP and abscess patients, as well as the saliva of sCAP patients. Controls showed the lowest OxS levels in both RC contents and saliva. Significant positive correlations between OxS markers, periapical index, and pain were revealed. Patients with pain had significantly higher OxS levels in both the endodontium (MPO median 27.9 vs 72.6 ng/mg protein, =0.004; OSI 6.0 vs 10.4,
ISSN:1178-7090
1178-7090
DOI:10.2147/JPR.S141366